Hematopoietic Stem Cell Transplantation: 1st Edition (Paperback) book cover

Hematopoietic Stem Cell Transplantation

1st Edition

Edited by Anthony D. Ho, Rainer Haas, Richard E. Champlin

CRC Press

624 pages

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Description

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more.

Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life.

Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation

  • summarizes current understanding and development of clinical allogeneic HSC transplantation

  • discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation

  • considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors

  • details detection of bone marrow contamination by tumor cells and removal procedures

  • focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors

  • explores the effects of growth factor administration and leukapheresis on PB stem cell donors

  • shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use

  • reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells

  • employs automated fluorescence image cytometry to study early HSC behavior following seeding

    Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study,

  • Table of Contents

    NOVEL CYTOKINES AND CELLULAR COMPONENTS

    Thrombopoietin: Basic Biology and Clinical Effects

    About the Editors

    Anthony D. Ho, Rainer Haas, Richard E. Champlin

    Subject Categories

    BISAC Subject Codes/Headings:
    MED000000
    MEDICAL / General
    MED038000
    MEDICAL / Hematology