Heparin-Induced Thrombocytopenia, Fifth Edition: 5th Edition (Hardback) book cover

Heparin-Induced Thrombocytopenia, Fifth Edition

5th Edition

Edited by Theodore E. Warkentin, Andreas Greinacher

CRC Press

592 pages | 38 Color Illus. | 78 B/W Illus.

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pub: 2012-10-23
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Although first reported in 1973, immune heparin-induced thrombocytopenia (HIT) remains one of the most frequent and devastating adverse drug reactions encountered by physicians. This thoroughly updated fifth edition from international experts Professors Warkentin and Greinacher is the gold standard for accurate diagnosis and management of this condition. Identifying key signs and symptoms and providing clear intervention strategies—including the use of alternative anticoagulants to manage critical circumstances—this is an essential resource for all clinicians and a "must" for hematology consultants.

Heparin-Induced Thrombocytopenia, Fifth Edition explores:

  • Clinical and laboratory studies on HIT
  • The immune basis and pathogenesis, animal models, and laboratory testing for HIT antibodies
  • Clinical features, differential diagnosis, scoring systems, and frequency of HIT in diverse clinical settings, including pediatric patients
  • Evidence-based guidelines for recognition, treatment, and prevention
  • Actions that should and should not be taken after the identification of HIT
  • Traditional and novel pharmacotherapies, current dosing guidelines, and the advantages and limitations of alternative anticoagulants
  • Selection criteria from a variety of new treatment options, helping physicians determine which of these agents are safe and effective for their patients

Table of Contents

History of Heparin-Induced Thrombocytopenia

Theodore E. Warkentin

Clinical Picture of Heparin-Induced Thrombocytopenia

Theodore E. Warkentin

Differential Diagnosis of Heparin-Induced Thrombocytopenia and Scoring Systems

Theodore E. Warkentin, Adam Cuker, MD, MS

Frequency of Heparin-Induced Thrombocytopenia

Lori-Ann Linkins, David H. Lee

Nonimmune Heparin-Platelet Interactions: Implications for the Pathogenesis of Heparin-Induced Thrombocytopenia

McDonald K. Horne III, Andreas Greinacher

Role of Heparin-Dependent Antigens in Immune Heparin-Induced Thrombocytopenia

Jean Amiral, Anne Marie Vissac

Role of Sulfated Polysaccharides and other Polyanions in the Pathogenesis of Heparin-Induced Thrombocytopenia

Susanne Alban, Krystin Krauel, Andreas Greinacher

Platelet and Leukocyte Fcγ Receptors in Heparin-Induced Thrombocytopenia

Gregory A. Denomme

Cellular and Molecular Immunopathogenesis of Heparin-Induced Thrombocytopenia

Lubica Rauova, Gowthami M. Arepally

Murine Models of Heparin-Induced Thrombocytopenia

Gowthami M. Arepally, Bruce S. Sachais, Douglas B. Cines, Mortimer Poncz, Lubica Rauova, Steven E. McKenzie

Laboratory Testing for Heparin-Induced Thrombocytopenia

Theodore E. Warkentin, Andreas Greinacher

Treatment of Heparin-Induced Thrombocytopenia: An Overview

Andreas Greinacher, Theodore E. Warkentin

Argatroban Therapy in Heparin-Induced Thrombocytopenia

Lawrence Rice, Martin Beiderlinden, Marcie J. Hursting

Recombinant Hirudin for the Treatment of Heparin-Induced Thrombocytopenia

Andreas Greinacher

Bivalirudin for the treatment of Heparin-Induced Thrombocytopenia

John R. Bartholomew, Jayne Prats, PhD.

Danaparoid for the Treatment of Heparin-Induced Thrombocytopenia

Beng Hock Chong, Harry N. Magnani

Fondaparinux and Other Emerging Anticoagulants to Treat Heparin-Induced Thrombocytopenia

Theodore E. Warkentin, John W. Eikelboom

Hemodialysis in HIT

Karl-Georg Fischer

Management of Intraoperative Anticoagulation in Patients with Heparin-Induced Thrombocytopenia Undergoing Cardiovascular Surgery

Sixten Selleng, Andreas Koster

Heparin-Coated Intravascular Devices and Heparin-Induced Thrombocytopenia

Theodore E. Warkentin

Heparin-Induced Thrombocytopenia in Children

Anne F. Klenner, Andreas Greinacher

A Clinician’s Perspective on Heparin-Induced Thrombocytopenia: Paradoxes, Myths, and Continuing Challenges

Lawrence Rice

About the Editors

Theodore E. Warkentin, MD, FACP, FRCPC is a professor in the Department of Pathology and Molecular Medicine, and the Department of Medicine, at McMaster University, Canada.

Prof. Dr. Andreas Greinacher is professor and head of the Department of Transfusion Medicine and the Hemostasis Service at the Medical School and Hospital of the Ernst-Moritz-Arndt-University Greifswald, CEO and chief of staff of the University Hospital Greifswald, and visiting professor at McMaster University Hamilton, Canada.

About the Series

Fundamental and Clinical Cardiology

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Cardiology
MEDICAL / Hematology