This book is destined to serve as a classic reference source to which researchers can turn for a historical perspective and basic information on the physiology, biochemistry, and pathology of the liver. Major areas covered in the book include histological organization, classification of chemical-induced injury, stages of cellular injury, and xenobiotic metabolism. Chapters discussing the use of biochemical methods to determine liver damage, the effects of various chemical agents of the liver, and hepatocarcinogenesis are also presented. Toxicologists, physiologists, physicians, biochemists, industrial hygienists, and others interested in the effects of chemical agents on the structure and function will find this book to be an indispensable source of information.
Histological Organization. Classification of Chemical-Induced Injury. Stages of Cellular Injury. Xenobiotic Metabolism. Liver Function Tests in the Differential Diagnosis of Hepatotoxicity. Use of Perfused Liver and Isolated Hepatocytes. Biochemical Methods of Studying Hepatotoxicity. Biochemical Aspects of Fatty Liver. Free Radical Damage and Lipid Peroxidation. Alterations in Porphyrin Metabolism. Alcohol Induced Hepatotoxicity. Cholestatic Mechanism of Liver Damage. Halogenated Hydrocarbons in Hepatotoxicity. Hepatocarcinogenesis. Peroxisome Proliferation. Immunological Methods for Investigating the Mechanism of Halothane-Induced Hepatotoxicity. c. 640 pp., 6x9, 144 illus., 25 tables, due May 1991, ISBN 0-8493-8810-4.