328 Pages
by
CRC Press
328 Pages
by
CRC Press
Also available as eBook on:
Clearly explaining the logical analysis of biological control phenomena, Biological Feedback answers questions concerning everything from regulation to logic. This rare monograph presents a formal methodology for analyzing the dynamic behavior of complex systems. The easy-to-read text describes a simple logical formalization called "kinetic logic". The reader discovers how this method is used to... Read more
PART I: TOOLS. Introduction to Part I. Elements of Combinatorial Logic. Kinetic Logic I: From Logical Structure to Behavior. Kinetic Logic II: The Conditions Determining the Choices Among Pathways. Inductive Use of Kinetic Logic. Elements of the Differential Description. Generalized Kinetic Logic. Generalized Logical vs. Differential Description. PART II: FEEDBACK LOOPS. Introduction to Part II. Simple Negative Feedback Loops Generate Homeostasis: Differential Description. Simple Negative Feedback Loops Generate Homeostasis: Logical Description. Simple Positive Feedback Loops Generate Differentiation: Differential Description. Simple Positive Feedback Loops Generate Multistationarity: Logical Description. How Can a Transient Signal Switch a Function on Permanently? Many Steady States. Systems with Positive and Negative Feedback Loops. PART III: APPLICATIONS. Epigenetic Differences and Multiple Steady States. The Logical Treatment of Diffusion. The SOS Response. Bacteriophage l. Logical Modelization of Neuronal Networks. A Model Analysis of the Immune Response. On Determination and Differentiation. Appendix 1: How to Find a Steady State Value by Iteration. Appendix 2: Trajectories and Evolution. Appendix 3: A Little More About Linear Stability Analysis. Appendix 4: Asynchronous vs. Synchronous Description. Index.
Biography
Rene Thomas, Richard D'Ari
