High-Throughput Analysis in the Pharmaceutical Industry: 1st Edition (Paperback) book cover

High-Throughput Analysis in the Pharmaceutical Industry

1st Edition

Edited by Perry G. Wang

CRC Press

432 pages

Purchasing Options:$ = USD
Paperback: 9780367387006
pub: 2019-09-25
Hardback: 9781420059533
pub: 2008-08-20
eBook (VitalSource) : 9780429137280
pub: 2008-08-20
from $120.00

FREE Standard Shipping!


The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corresponding revolutionary improvement to the conventional methodology must happen.

Table of Contents

High-Throughput Sample Preparation Techniques and Their Application to Bioanalytical Protocols and Purification of Combinatorial Libraries. On-line Sample Extraction Coupled with Muliplexing Strategy to Improve Throughput. Optimizing LC/MS Equipment to Increase Throughput in Pharmaceutical Analysis. Throughput Improvement of Bioanalytical LC/MS/MS by Sharing Detector between HPLC Systems. High-Throughput Strategies for Metabolite Identification in Drug Discovery. Utilizing Microparallel Liquid Chromatography for High-Throughput Analyses in the Pharmaceutical Industry. Strategies and Techniques for Higher Throughput ADME/PK Assays. High-Throughput Analysis in Drug Metabolism During Early Drug Discovery. High-Throughput Analysis in Support of Process Chemistry and Formulation Research and Development in the Pharmaceutical Industry. Online Solid Phase Extraction LC/MS/MS for High-Throughput Bioanalytical Analysis. Applications of High-Throughput Analysis in Therapeutic Drug Monitoring. High-Throughput Quantitative Pharmaceutical Analysis in Drug Metabolism and Pharmacokinetics Using Liquid Chromatography–Mass Spectrometry. Designing High-Throughput HPLC Assays for Small and Biological Molecules. Advances in Capillary and Nano HPLC Technology for Drug Discovery and Development. High-Throughput Analysis of Complex Protein Mixtures by Mass Spectrometry. Index

About the Editor

Perry G. Wang

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacy
SCIENCE / Chemistry / General
SCIENCE / Chemistry / Analytic