High Throughput Screening: The Discovery of Bioactive Substances, 1st Edition (Hardback) book cover

High Throughput Screening

The Discovery of Bioactive Substances, 1st Edition

By John P. Devlin

CRC Press

704 pages

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Hardback: 9780824700676
pub: 1997-05-06
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Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.



…a valuable reference.

"-Journal of Pharmacy and Pharmacology

"…a well-referenced, highly professional, comprehensive, and in-depth treatment of a relatively complex approach to the discovery of bioactive substances….

…a recommended book for most private libraries of both academic and industrial pharmaceutical and agricultural chemists and biologists and a must acquisition for applicable and industrial libraries.

"-Journal of Medicinal Chemistry

"…an excellent compendium…covering the breath of current HTS. It will serve as a standard text in the field.

"-Journal of Natural Products

This recommendable book should be of great value for the entry in high throughput screening systems in industry and research. It gives a very useful and clear description of the development of HTS systems from finding resources and generating libraries to assay and detection methods and finally automation, data handling and laboratory design.

- European Journal of Pharmaceutics and Biopharmaceutics, 2000

Table of Contents

Natural Products as a Discovery Resource, edited by John P. Devlin

Chemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds, John P. Devlin

Microcollection of Plants for Biochemical Profiling, John P. Devlin

Enzymes and Microbes as a Source of Chemical Diversity, Saul L. Neidleman

The Marine Environment as a Discovery Resource, Gregg R. Dietzman

Compound Sourcing: Chemically Generated Screening Libraries, edited by Michael R. Pavia

Introduction, Michael R. Pavia

Rapidly Expanding Molecular Diversity: Libraries from Libraries, John S. Kiely, Barbara Dörner, John M. Ostresh, Colette Dooley, and Richard A. Houghten

Synthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS, Jack J. Baldwin and Ian Henderson

Parallel Organic Synthesis Using Parke-Davis' Diversomer® Method, Sheila Hobbs DeWitt and Anthony W. Czarnik

Rapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods, Adnan M. M. Mjalli and Barry E. Toyonaga

CMT: A Solution Phase Combinatorial Chemistry Approach: Synthesis and Yield Prediction Phenazines, Ferenc Darvas and László Kovács

Design of a Diverse Screening Library, David E. Patterson, Allan M. Ferguson, Richard D. Cramer, Cheryl D. Garr, Ted L. Underiner, and John R. Peterson

Automating Combinatorial Chemistry: Challenges and Pitfalls, Jill H. Hardin and Frank R. Smietana

Combi-chem High Throughput Screening for Leads Optimization, Richard M. Kris, Patti Willson, Serene Josiah, Marianne Wildgoose, Helen Yeoman, Viktor Krchnak, Stephen Baum, and Stephen Felder

Assay Technologies and Detection Methods, edited by Alfred J. Kolb

Introduction, Alfred J. Koin

Bioassay Design and Implementation, Robert W. Wallace and Mark E. Goldman

Scintillation Proximity Assays, Martino Picardo and Kelvin T. Hughes

FlashPlate™ Technology, Beverly A. Brown, Margaret Cain, Jeff Broadbent, Sharon Tompkins, Georgette Henrich, Rich Joseph, Sally Casto, Harry Harney, Rick Greene, Ron Delmondo, and Simon Ng

Assays for Small Molecule Agonists and Antagonists of the Neurotrophin Receptors, Maureen H. Beresini, Michael D. Sadick, Amy L. Galloway, Randy Yen, Sherry H. Yeh, Andy C. Chang, David L. Shelton, and Wai Lee T. Wong

A Homogeneous, Time-Resolved Fluorescence Method for Drug Discovery, Alfred J. Kolb, Jocelyn W. Burke, and Gerard Mathis

Time-Resolved Fluorometry: Advantages and Potentials, Ilkka Hemmilä

Adaptation of Time-Resolved Fluorescence to Homogeneous Screening Formats, Janet M. Kolb, Greg Yamanaka, and Susan P. Manly

Fluorescence Polarization, J. Richard Sportsman, Sandra K. Lee, Hara Dilley, and Robert Bukar

Reporter Gene Assay Applications, Winfried Scheirer

Development of a Gene Expression-Based Screen Using Quantitative Polymerase Chain Reaction, D. K. H. Lee, E. T. Wilkinson, S. Cheifetz, and S. A. De Grandis

High-Performance Microphysiometry in Drug Discovery, M. Liisa Alajoki, Gregory T. Baxter, William R. Bemiss, David Blau, Luc J. Bousse, Samuel D. H. Chan, Timothy D. Dawes, Karen M. Hahnenberger, James M. Hamilton, Philip Lam, Richard J. McReynolds, Douglas N. Modlin, John C. Owicki, J. Wallace Parce, Dana Redington, Knute Stevenson, H. Garrett Wada, and Jana Williams

Bioanalytical Applications of BIAcore, an Optical Biosensor, Francois Legay, Patrick Albientz, and Rüdiger Ridder

Automation and Robotics, edited by Alfred J. Kolb

Introduction, Alfred J. Kolb

Management and Service Issues of a Centralized Robotic HTS Core, John Babiak

Flexible Use of People and Machines, Mark Beggs and John S. Major

Bar-Code Technology and a Centralized Database: Key Components in a Radioligand Binding Program, Elizabeth A. Kunysz, Melissa Lukes, and Douglas W. Bonhaus

Factors for the Successful Integration of Assays, Equipment, Robotics, and Software, Dejan Bojanic, Wilma W. Keighley, Mike J. Russell, and Terry P. Wood

Accelerating the Discovery Process with Automation and Robotics: A Sure Bet or a Risky Venture?, Richard K. Brown and Andree Proulx

Perspectives on Scheduling, Alain Donzel, Jorge Carmona, and L. Andrew Corkan

Data Retrieval, Handling, and Integration, edited by John P. Devlin

Introduction, John P. Devlin

Database Systems, Barr E. Bauer

Systems Integration, Chip Allee

Data Management and Tracking for Natural Product Programs, Gregg R. Dietzman

Laboratory Design and Management, edited by Matthew A. Sills

Introduction, Matthew A. Sills

Planning and Implementing an HTS Program, Matthew A. Sills and Mark Crawford

Establishing an HTS Program in a Start-up Biotechnology Company, Michael D. Boisclair, James Schultz, and Dan Maloney

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacy
SCIENCE / Chemistry / General