Principles and Practices
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An exploration of high-throughput synthesis, this book presents a compilation of how-to methods, novel materials, and catalyst developments for creating a multitude of new compounds. Introductory sections are coupled with in-depth case studies clarifying theory through practice. The book emphasizes the potential for reproducing experiments in detail.
Table of Contents
Theory and methods in solid phase organic synthesis: an introduction to solid phase organic synthesis; methods of analysis to determine the progress of a chemical reaction on solid support. High throughput synthesis for drug discovery: high throughput organic synthesis - a perspective looking back on 10 years of combinatorial chemistry; techniques and strategies for producing compound libraries for biological screening; high throughput purification strategies; automating high throughput organic synthesis. High throughput synthesis of new materials and catalysts: synthesis and high throughput evaluation of complex functional materials chips; high throughput screening of catalyst libraries. New directions in high throughput synthesis: microfluidic analysis, screening and synthesis; sensors; the use of magnetic separation coupled with power ultrasound for high throughput solid phase organic synthesis.