1st Edition

Histopathologic Diagnosis of Invasive Mycoses

By Henrik Elvang Jensen Copyright 2023
    239 Pages 277 Color & 3 B/W Illustrations
    by CRC Press

    239 Pages 277 Color & 3 B/W Illustrations
    by CRC Press

    239 Pages 277 Color & 3 B/W Illustrations
    by CRC Press

    Written by one of the very few pathologists who has real expertise in this field, this book is a comprehensive key for the identification of fungal infections in tissues. With updated terminology and presentation, all invasive mycoses-types are covered, detailing their epidemiology, pathology, histomorphology of fungal elements, and differential diagnoses. Each of the separate fungal groups has a good combination of text and high-quality illustrations which is a critical feature for clinicians to state the mycopathological diagnoses.

    Key Features:
    1. Elaborates on the histological observations of both the pathological reaction and the histomorphology of fungal elements, guiding the reader in the right direction for obtaining a diagnosis of the infection.
    2. Includes key observations that can be a game-changer for infectious diseases specialists and histopathologists studying the combination of fungal morphology and host response.
    3. Follows a logical layout, structure, and organization with a wealth of high-quality illustrations of the various fungi in tissues elucidated by different stains.


    About the author

    1. Introduction

    2. Histopathological classification of invasive mycoses

    3. Histopathological staining of invasive fungi

    4. Pathomorphological identification of invasive fungi

    5. Identification of invasive fungi using in situ techniques

    6. Glossary of medical mycology

    7. Aspergillosis

    8. Fusariosis

    9. Scedosporiosis and lomentosporiosis

    10. Mucormycosis

    11. Entomophthoromycosis

    12. Pythiosis

    13. Hyalohyphomycosis, minor

    14. Phaeohyphomycosis

    15. Chromoblastomycosis

    16. Mycetomas

    17. Candidosis

    18. Trichosporonosis

    19. Cryptococcosis

    20. Blastomycosis

    21. Histoplasmosis capsulati

    22. Histoplasmosis duboisii

    23. Paracoccidioidomycosis

    24. Sporotrichosis

    25. Talaromycosis

    26. Pneumocystosis

    27. Lacaziosis

    28. Coccidioidomycosis

    29. Adiaspiromycosis

    30. Rhinosporidiosis

    31. Rare mycoses

    32. Algoses



    Professor Henrik Elvang Jensen has served as a pathologist for nearly 40 years and has had the privilege of receiving fungal infection cases from all over the world for diagnostic consultation. Therefore, he has been able to collect several cases of almost all kinds of invasive fungal infections in humans and animals. Moreover, he has on a yearly basis given lectures and courses on the histomorphological diagnosis of mycoses in several countries and arranged pre-congress workshops at different world congresses including the ISHAM congresses in Berlin (2012), Melbourne (2015), Amsterdam (2018) on the same topic. During the years, he has published more than 100 peer review papers and chapters in textbooks and being a co-author of more international guidelines all dealing with the histopathological diagnosis of invasive mycoses.

    With his 1st edition of Histopathologic Diagnosis of Invasive Mycoses, Henrik Elvang Jensen introduced what has the potential to become a standard reading for early-career as well as experienced pathologists. Colleagues from other specialties will benefit from this reading, as this book not only succeeds in educating on how to diagnose fungal diseases based on histopathological findings but also in providing a comprehensive overview on the diversity of fungal diseases in patients with a wide range of underlying diseases.
    Henrik Elvang Jensen has taken on a challenging task to provide experienced and inexperienced clinicians with a comprehensive but concise handbook about histopathological diagnosis in mycology. Timely diagnosis of fungal infection, assessment of invasiveness and the identification of the causative pathogen are key for tailored therapeutic decision making that will save lives. Histopathology is an essential part in diagnostics, usually the first stop on the road to a confirmed diagnosis.
    With the growing number of patients at risk for fungal infections and the expanding spectrum of causative fungal pathogens, it becomes more and more pressing to train pathologists adequately to be aware of a possible fungal infection and how to differentiate fungal infections from other more commonly suspected findings, especially in patients with co morbidities. A vital task, considering the high mortality rates in respective patients. Due to the general low incidence of most fungal diseases, gaining hands-on experience in identifying and morphological differentiating fungal diseases is rather difficult for pathologists and requires years-long training.
    This book guides the reader through the ever-growing armamentarium of fungal infections, each chapter devoted to one fungal disease and its histopathological features. As diverse as the patient populations at risk for fungal infections and the causative fungal pathogens are, as diverse are the clinical and consequently morphological manifestations these infections come in. Jensen allows the reader to look over his shoulder while he lays out the disease-specific changes in cell and tissue morphology and architecture, fungus by fungus, disease by disease. In high-resolution images he presents and explains characteristic histopathological findings in tissue sections dyed with one or more stains, moving his microscope from superficial to invasive infections, from the most common infections including aspergillosis, candidosis, cryptococcosis, coccidioidomycosis and histoplasmosis to the less common and rare infections, from omnipresent to endemic infections.
    Jensen’s many years of experience in pathology and his passion for mycology allows him to provide the reader with this structured overview that will help generations of pathologists to further improve their skills in spotting the often-overlooked fungal bodies and interpret the composition of cells in this context in any tissue, in any patient. A must-have for every microbiologist, pathologist and infectious diseases physician.

    Danila Seidel PhD and Oliver A. Cornely MD
    ECMM Diamond Excellence Center, Department I of Internal Medicine, University Hospital Cologne and CECAD Cluster of Excellence, Translational Research Infectious Diseases, University of Cologne, Germany