Human genetics has blossomed from an obscure biological science and explanation for rare disorders to a field that is profoundly altering health care for everyone. This thoroughly updated new edition of Human Genetics: The Basics provides a concise background of gene structure and function through the lens of real examples, from families living with inherited diseases to population-wide efforts in which millions of average people are learning about their genetic selves. The book raises compelling issues concerning:
• The role of genes in maintaining health and explaining sickness
• Genetic testing, gene therapy, and genome editing
• The common ancestry of all humanity and how we are affecting our future.
Written in an engaging, narrative manner, this concise introduction is an ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all.
"A fascinating and informative introduction to the topic of human genetics. This excellent book would be suitable for anyone wishing to obtain a better understanding of genetic topics, especially those related to human health and disease." Elaine Hemers, Liverpool John Moores University, UK
The second edition of this excellent book gives a comprehensive overview of the expanding field of human genetics. Easy to read and illustrated with real life examples the book is enjoyable to read for everyone interested in human genetics, both lay persons and professionals. Katarina Pelin, University of Helsinki, Finland
List of Figures & Tables
Chapter 1. From Mendel’s Peas to Double Helices
From Genes to Genomes
Agriculture is Applied Genetics
Mendel’s Experiments —The Mystery of the Missing Traits
The Chromosome Connection
In Pursuit of the Genetic Material
Chapter 2. How Genes Work
A Brief History of CF
The Individual Level: Tissues and Organs
The Family Level
Chapter 3. Genes and Health
A Genomic View of Health
Causes of Death – An Organizing Framework
Cancer: The Cell Cycle Out of Control
The Microbiome and Infectious Disease
Chapter 4. Genetic Testing
The First Generation of Genetic Tests: Proteins
The Second Generation of Genetic Tests: DNA
The Third Generation of Genetic Tests: Exomes and Genomes
Chapter 5. Gene Therapy and Genome Editing
Protein Therapy Came First
Gene and Genome Editing
Chapter 6. From Ancestry to Destiny
DNA as Clock and Compass
The First Hominins
DNA Evidence Overlaps Fossil Evidence
Expansion Out of Africa
From Archaic Humans to Modern Humans
Genetic Genealogy and Ancestry Testing
The Future: Will Humanity Homogenize or Diverge?
The Basics is a highly successful series of accessible guidebooks which provide an overview of the fundamental principles of a subject area in a jargon-free and undaunting format.
Intended for students approaching a subject for the first time, the books both introduce the essentials of a subject and provide an ideal springboard for further study. With over 50 titles spanning subjects from Artificial Intelligence to Women’s Studies, The Basics are an ideal starting point for students seeking to understand a subject area.
Each text comes with recommendations for further study and gradually introduces the complexities and nuances within a subject.