Human Placental Trophoblasts: Impact of Maternal Nutrition, 1st Edition (Hardback) book cover

Human Placental Trophoblasts

Impact of Maternal Nutrition, 1st Edition

Edited by Asim K. Duttaroy, Sanjay Basak

CRC Press

426 pages | 35 B/W Illus.

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pub: 2015-11-03
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Human Placental Trophoblasts: Impact of Maternal Nutrition explores the vital roles of trophoblasts play in fetal growth and pregnancy, giving you new insight into the modulation of placental trophoblast functions by nutrients. It also reviews the role of fatty acids, folic acids, and specific vitamins in this aspect. The book highlights the critical role of nutrients on human placental development and its' in utero programming effects on the development of chronic diseases such as type 2 diabetes, cardiovascular diseases, hypertension, and obesity in later life.

The book begins with discussions of the central process of placentation and its regulation on size and growth of the fetus. It also covers the effects of key macronutrients on placental growth, metabolism, transport, and secretory function. The text details important vitamins and few micronutrients and their roles in the feto-placental growth and development. It includes information on the influence of maternal lifestyle and environmental factors on regulation of the growth, metabolism and gene expression in the feto-placental unit. A review of the genes linked to the process of placentation rounds out the coverage.

An examination of a broad range of evidence in the areas of placental growth, function, and its impact on feto-placental outcome, the book presents new knowledge on nutrition and its relevance with early human development. This includes not only the effects of maternal nutrients on possible neonatal growth and development but also their regulation by maternal lifestyle associated factors. A fine blending of epidemiology, clinical nutrition, perinatal and neonatal medicine, and biochemistry and molecular biology areas of research activities, the book helps you to understand the impact of maternal nutrition on placentation and its relevance with pregnancy outcome and fetal programming of adult health and disease.

Table of Contents


Human Placenta Development, Structure, and Organization in Relation to Function and Fetal Development

T. Henriksen, A.M. Holme, H. Horne, M.B. Holm, and T.M. Michelsen

Molecular Regulation of Human Extravillous Trophoblast Development

JÜrgen Pollheimer and Martin Knöfler

Epigenetics and the Placenta: Impact of Maternal Nutrition

Leslie Myatt and Kohzoh Mitsuya

Maternal Diet, Trophoblast Biology, and Epigenetic Regulation

Daniel Vaiman


Prepregancy Nutrition and Pregnancy Outcome

Christine Henriksen

Placental Amino Acid Transport in Response to Maternal Nutrition during Pregnancy

Allison L.B. Shapiro and Theresa L. Powell

Fatty Acid Uptake and Metabolism in the Human Placenta

Asim K. Duttaroy

The Roles of Fatty Acids in Fetal Development

Emilio Herrera and Henar Ortega-Senovilla

Role of Maternal Long-Chain Polyunsaturated Fatty Acids in Placental Development and Function

Alka Rani, Akshaya Meher, Nisha Wadhwani, and Sadhana Joshi

Importance of Cholesterol and Cholesterol Transporters in the Placental Trophoblast during Pregnancy

Arjun Jain and Christiane Albrecht

Maternal Fatty Acids and Their Effects on Placentation

Sanjay Basak and Asim K. Duttaroy


Maternal Micronutrients, Placental Growth, and Fetal Outcome

Irene Cetin, Chiara Mandò, and Manuela Cardellicchio

Folic Acid Uptake and Its Regulation in the Placenta

E. Keating, J.R. Araújo, and F. Martel

Vitamin D Effects on Pregnancy and Trophoblast Function: Limited Data yet Endless Possibilities

Bryanne Colvin, Mark S. Longtine, and D. Michael Nelson

Choline and Placental Trophoblast Development

Sze Ting (Cecilia) Kwan, Julia H. King, and Marie A. Caudill

Role of Calcium in Fetal Development

Evemie Dubé and Julie Lafond


Maternal Obesity and Placental Vascular Function

Louiza Belkacemi, Michael G. Ross, and Mina Desai

Placental Dysfunction and Future Maternal Cardiovascular Disease

Anne Cathrine Staff and Christopher W.G. Redman

Trophoblast-Uterine Natural Killer Cell Interactions and Their Effect on Cytokines and Angiogenic Growth Factors

Gendie E. Lash and Judith N. Bulmer

Hyperglycemia on Trophoblast Invasion and Angiogenesis

Sanjay Basak and Asim K. Duttaroy

Role of Cytokines in Healthy and Pathological Pregnancies

Abhilash D. Pandya, Mrinal K. Das, and Johannes Rolin


The Aryl Hydrocarbon Receptor in the Human Placental Trophoblast: The Impact of Nutraceuticals and Naturals Products

Petr Pavek and Tomas Smutny

Impact of Environmental Pollutants on Placentation

Nur Duale, Kristine Bjerve Gutzkow, Tim Hofer, and Birgitte Lindeman


Differential Gene Expression of the Placenta in Normal and Pathological Human Pregnancy

Vasilis Sitras and Ganesh Acharya

Placental Gene Expression in Pathological Pregnancies

Saumitra Chakravarty

Regulation of microRNA Expression and Function of First-Trimester and Term Placentas in Humans

Yuping Wang

About the Editors

Dr. Asim K. Duttaroy was educated in India and USA. Currently he is the Professor and group leader, Chronic disease, Dept. of Nutrition, Faculty of Medicine at the University of Oslo, Norway. After his fellowship at the Thrombosis Research Centre, Temple University Medical School, he joined as an Assistant Professor of Medicine and Biochemistry at the Wright State University, and Senior Health Scientist at the VA Medical Centre, Dayton, Ohio. He then moved to the Rowett Research Institute of Aberdeen University, Scotland, UK as the Professor and the Principal Scientist. In 2001, he was appointed as Professor and Group leader at the University of Oslo, Norway. His research program focuses on the roles of dietary components on growth, development, as well as in the prevention of cardiovascular disease. He is investigating the mechanisms responsible for cellular growth, function and metabolism of dietary lipids in feto-placental unit. He holds several international patents. His discovery Fruitflow™ is scientifically-proven to inhibit platelet aggregation, a known cause of heart attack, stroke and venous thrombosis. It became the first product in Europe to obtain an approved positive health claim under the European Food Safety Authority (EFSA) regulations. Prof. Duttaroy is a member of several International societies and editorial board of several international journals. Recently he was appointed as the Editor-In-Chief of Food & Nutrition Research journal. His scientific work has been published in over 175 original contributions, reviews , book, book chapters, and editorials. He has supervised 25 PhD/MD students so far. He has personal website where his activities are regularly updated.

Dr. Sanjay Basak is a Researcher. At present he is working as a Scientist at the Division of Molecular Biology, National Institute of Nutrition (ICMR), India. After receiving his PhD in Biochemistry, he joined as a Research Officer to this institute. Recently he completed his research training fellowship in Nutrition, Physiology and Molecular Biology from the Institute of Basic Medical Sciences, University of Oslo, Norway. His research is actively involved in molecular aspects of nutrition, trophoblast growth, development and placentation. He secured a competitive overseas research fellowship grant (BOYSCAST) from Govt. of India. He was a recipient of Henrik Homans Memorial Scholarship, Norway. Currently, he is associated as an Editorial Member of the peer-reviewed international journal “Food and Nutrition Research”, Co-action Publisher, Sweden. Till date, he has published 16 research articles, 2 review papers and one book chapter. Most of his work is available at

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Nutrition
MEDICAL / Perinatology & Neonatology
MEDICAL / Reproductive Medicine & Technology
SCIENCE / Life Sciences / Biology / Molecular Biology