The most profound dilemma in assisted reproduction to date is the inability to recognize potentially viable embryos before their replacement into the reproductive tract. Application of increasingly advanced new technology has allowed the field of embryo evaluation to evolve rapidly and dramatically over the past five years.
Human Preimplantation Embryo Selection assembles the leaders in the field of assisted reproduction to discuss their visions of dealing with the topic of embryo selection in the light of the limitations involving the fragility of the early human embryo.
The purpose of this book is to shed light on the ever-expanding techniques that are being employed and evaluated with regard to embryo selection. A comprehensive overview may guide the ART practitioner in choice of techniques and evaluation of benefits and drawbacks.
This book will provide an up-to-date overview and reference source: an invaluable tool for assisted reproductive practice worldwide.
Table of Contents
Assessment of The Human Oocyte and Embryo Morphology. The Zona Pellucida And Markers of Viability. Morphology and Kinetics of Human Pronuclei. Human Pronuclei as a Mode of Predicting Viability. Human Multi-Nucleation and Mosaicism. Fragmentation: Meiotic and Mitotic Mechanisms. Analysis of Blastocyst Morphology. Morphometrics of The Human Embryo. Development Rate, Cumulative Scoring and Embryonic Viability. Cryopreservation and Its Effect on Embryo Morphology. Manipulating Embryo Development. Assessment of Shla-G in Human Embryos. Immunological Aspects of Embryo Development. Nitric Oxide Regulation of The Embryo. Uptake and Release of Metabolites. Preimplantation Embryo Metabolism and Embryo Interaction with the In-Vitro Environment. Polar Body Chromosomes and Consequences for Human Embryo Development. Chromosomal Status in Human Blastomeres. Genomic Imprinting and Consequences for Embryonic Development. Selection of Viable Embryos and Gametes by Rapid, Non-Invasive Metabolomic Profiling of Oxidative Stress Biomarkers. Gene Expression Analysis in the Human Oocyte and Embryo. Mitochondria in Reproduction: Future Assays for Embryo Selection. Future Genetic and Other Technologies for Embryo Assessment. Do Follicular Markers of Oocyte Competence Exist? Sperm DNA and Embryo Development. The Sperm Centriole: Its Effect on the Developing Embryo