This comprehensive book focuses on multimodality imaging technology, including overviews of the instruments and methods followed by practical case studies that highlight use in the detection and treatment of cardiovascular diseases. Chapters cover PET-CT, SPECT-CT, SPECT-MRI, PET-MRI, PET-optical imaging, SPECT-optical imaging, photoacoustic Imaging, and hybrid intravascular imaging. It also addresses the important issues of multimodality imaging probes and image quantification.
Readers from radiology and cardiology as well as medical imaging and biomedical engineering will learn essentials of the field. They will be shown how the field has advanced quantitative analysis of molecularly targeted imaging through improvements in the reliability and reproducibility of imaging data. Moreover, they will be presented with quantification algorithms and case illustrations, including coverage of such topics such as multimodality image fusion and kinetic modeling.
Yi-Hwa Liu, PhD is Senior Research Scientist in Cardiovascular Medicine at Yale University School of Medicine and Technical Director of Nuclear Cardiology at Yale New Haven Hospital. He is also an Associate Professor (Adjunct) of Biomedical Imaging and Radiological Sciences at National Yang-Ming University, Taipei, Taiwan, and Professor (Adjunct) of Biomedical Engineering at Chung Yuan Christian University, Taoyuan, Taiwan. He is an elected senior member of Institute of Electrical and Electronic Engineers (IEEE) and a full member of Sigma Xi of The Scientific Research Society of North America.
Albert J. Sinusas, M.D., FACC, FAHA is Professor of Medicine (Section of Cardiovascular Medicine) and Radiology and Biomedical Imaging, at Yale University School of Medicine, and Director of the Yale Translational Research Imaging Center (Y-TRIC), and Director of Advanced Cardiovascular Imaging at Yale New Haven Hospital. He is a recipient of the Society of Nuclear Medicine’s Hermann Blumgart Award.
Table of Contents
PRINCIPLES, INSTRUMENTATION, TECHNIQUES, APPLICATIONS AND CASE ILLUSTRATIONS OF HYBRID IMAGING. Principles and Instrumentation of SPECT/CT. Cardiovascular PET/CT. Development of a Second Generation Whole Body Small Animal SPECT/MR Imaging System. Integrated PET and MRI of the Heart. CT-MRI. Hybrid X-Ray Luminescence and Optical Imaging. X-ray Fluoroscopy – Echocardiography. Combined Ultrasound and Photoacoustic Imaging. Hybrid Intravascular Imaging in the Study of Atherosclerosis. MULTIMODALITY PROBES FOR HYBRID IMAGING. Preclinical Evaluation of Multimodality Probes. Multimodality Probes for Cardiovascular Imaging. QUANTITATIVE ANALYSES AND CASE ILLUSTRATIONS OF HYBRID IMAGING. Recent Developments and Applications of Hybrid Imaging Techniques. Multimodality Image Fusion. Quantitative Cardiac SPECT/CT. Evaluations of Cardiovascular Diseases with Hybrid PET-CT Imaging. Quantitative Analyses and Case Studies of Hybrid PET-MRI Imaging. Merging Optical with Other Imaging Approaches. FUTURE CHALLENGES OF HYBRID IMAGING TECHNIQUES. Hybrid Instrumentation versus Image Fusion: Path to Multibrid Visualization. Concerns with Radiation Safety.