1st Edition

IgE and Anti-IgE Therapy in Asthma and Allergic Disease

Edited By Robert Fick Copyright 2002

    Exploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders.

    Compiles previously unpublished data from the first extensive scientific investigations of Xolair!

    IgE and Anti-IgE Therapy in Asthma and Allergic Disease

  • reviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe
  • offers novel methods for the design and formulation of monoclonal antibodies
  • discusses the use of allergen bronchoprovocation to identify the characteristics and efficacy of new antiasthma and antiallergy medications
  • examines the role of IgE in food and parasitic allergies
    and covers
  • the pathogenesis of atopic dermatitis and urticaria
  • novel strategies to target mast cells and basophils
  • murine models of allergic pulmonary inflammation
  • the pathophysiology of allergic rhinitis
    Supplemented with nearly 2000 contemporary references to facilitate further study, IgE and Anti-IgE Therapy in Asthma and Allergic Disease is an in-depth and timely source for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medical school students in these disciplines.
  • Introduction

    James D. Reimann, Sharon Safrin, and Robert B. Fick, Jr.

    Understanding the Binding of IgE to Its High-Affinity Receptor and to an Anti-IgE Antibody
    Leonard G. Presta and Robert L. Shields

    Mediator Release from Basophils and Mast Cells and Its Relationship to FceRI Expression and IgE-Suppressing Therapies
    Donald W. MacGlashan, Jr., John T. Schroeder, Lawrence M. Lichtenstein, Sarbjit S. Saini, and Bruce S. Bochner

    Expression of IgE Receptors on Eosinophils
    David Dombrowicz, André Capron, and Monique Capron

    Eosinophil IgE Receptors: Controversy and Consensus
    Hirohito Kita and Cheryl R. Adolphson

    Murine Models of Asthma: Caveats and Conclusions on the Contribution of IgE and Mast Cells to Allergic Inflammation, Airway Hyperresponsiveness, and Airflow Obstruction
    Jeffrey S. Tepper and Daniel B. Tumas

    Role of IgE in Asthma: Pathogenesis and Novel Therapeutic Strategies
    James Laurence Lordan, Stephen T. Holgate, and Ian Sayers

    IgE-Mediated Response to Allergen in the Bronchoprovocation Laboratory
    Louis-Philippe Boulet and Donald W. Cockcroft

    Pathophysiology of the Airway Response to Inhaled Allergen in Asthmatic Subjects: Role of IgE
    John V. Fahy

    Efficacy and Safety of Xolair Anti-IgE Monoclonal Antibody in Adult Asthmatics
    Robert B. Fick, Jr., and W. James Metzger

    The Role of IgE in Pediatric Asthma
    Henry Milgrom and Charles Johnson

    Anti-inflammatory Activities of Omalizumab (Xolair), a Recombinant Humanized Monoclonal Antibody Binding IgE
    Robert B. Fick, Jr.

    Pulmonary Delivery of Anti-IgE: Rationale for Topical Delivery to the Airway
    Theresa D. Sweeney, Melinda Marian, Jane Ruppel, and Jeanine L. Bussiere

    Treatment of Seasonal Allergic Rhinitis
    Thomas B. Casale and Patricia W. Rohane

    Anti-IgE and Allergic Skin Diseases
    Michaël F. Hofer and Donald Y. M. Leung

    Role of IgE and Food Allergens
    Ricki M. Helm and A. Wesley Burks

    Role of IgE in Allergic Bronchopulmonary Aspergillosis
    Priscilla S. A. Sarinas and Rajinder K. Chitkara

    IgE and Its Role in Parasitic Helminth Infection: Implications for Anti-IgE-Based Therapies
    Philip J. Cooper and Thomas B. Nutman

    The Rise of Antibodies as Therapeutics
    Maureen P. Quan and Paul Carter

    Author Index


    Robert Fick