1st Edition

Image Analysis and Modeling in Ophthalmology

    412 Pages 166 B/W Illustrations
    by CRC Press

    412 Pages 166 B/W Illustrations
    by CRC Press

    Digital fundus images can effectively diagnose glaucoma and diabetes retinopathy, while infrared imaging can show changes in the vascular tissues. Likening the eye to the conventional camera, Image Analysis and Modeling in Ophthalmology explores the application of advanced image processing in ocular imaging. This book considers how images can be used to effectively diagnose ophthalmologic problems. It introduces multi-modality image processing algorithms as a means for analyzing subtle changes in the eye. It details eye imaging, textural imaging, and modeling, and highlights specific imaging and modeling techniques.

    The book covers the detection of diabetes retinopathy, glaucoma, anterior segment eye abnormalities, instruments on detection of glaucoma, and development of human eye models using computational fluid dynamics and heat transfer principles to predict inner temperatures of the eye from its surface temperature. It presents an ultrasound biomicroscopy (UBM) system for anterior chamber angle imaging and proposes an automated anterior segment eye disease classification system that can be used for early disease diagnosis and treatment management. It focuses on the segmentation of the blood vessels in high-resolution retinal images and describes the integration of the image processing methodologies in a web-based framework aimed at retinal analysis.

    The authors introduce the A-Levelset algorithm, explore the ARGALI system to calculate the cup-to-disc ratio (CDR), and describe the Singapore Eye Vessel Assessment (SIVA) system, a holistic tool which brings together various technologies from image processing and artificial intelligence to construct vascular models from retinal images. The text furnishes the working principles of mechanical and optical instruments for the diagnosis and healthcare administration of glaucoma, reviews state-of-the-art CDR calculation detail, and discusses the existing methods and databases.

    Image Analysis and Modeling in Ophthalmology includes the latest research development in the field of eye modeling and the multi-modality image processing techniques in ocular imaging. It addresses the differences, performance measures, advantages and disadvantages of various approaches, and provides extensive reviews on related fields.

    Ultrasound Biomicroscopic Imaging of the Anterior Chamber Angle

    Maria Cecilia Aquino and Paul Chew

    Automated Glaucoma Identification Using Retinal Fundus Images: A Hybrid Texture Feature Extraction Paradigm

    Muthu Rama Krishnan Mookiah, U Rajendra Acharya, Chandan Chakraborty, Lim Choo Min, Eddie Y K Ng, and Jasjit S Suri

    Ensemble Classification Applied to Retinal Blood Vessel Segmentation: Theory and Implementation

    Muhammad Moazam Fraz and Sarah A Barman

    Computer Vision Algorithms Applied to Retinal Vessel Segmentation and Quantification of Vessel Caliber

    Muhammad Moazam Fraz and Sarah A Barman

    Segmentation of the Vascular Network of the Retina

    Ana Maria Mendonça, Behdad Dashtbozorg, and Aurélio Campilho

    Automatic Analysis of the Microaneurysm Turnover in a Web-Based Framework for Retinal Analysis

    Noelia Barreira, Manuel G Penedo, Sonia González, Lucía Ramos, Brais Cancela, and Ana González

    A-Levelset-Based Automatic Cup-to-Disc Ratio Measurement for Glaucoma Diagnosis from Fundus Image

    Jiang Liu, Fengshou Yin, Damon Wing Kee Wong, Zhuo Zhang, Ngan Meng Tan, Carol Cheung, Mani Baskaran, Tin Aung, and Tien Yin Wong

    The Singapore Eye Vessel Assessment System

    Qiangfeng Peter Lau, Mong Li Lee, Wynne Hsu, and Tien Yin Wong

    Quantification of Diabetic Retinopathy Using Digital Fundus Images

    Hasan Mir, Hasan Al-Nashash, and U Rajendra Acharya

    Diagnostics Instruments for Glaucoma Detection

    Teik-Cheng Lim, U Rajendra Acharya, Subhagata Chattopadhyay, Jasjit S Suri, and Eddie Y K Ng

    Automated Cup-to-Disc Ratio Estimation for Glaucoma Diagnosis in Retinal Fundus Images

    Irene Fondón, Carmen Serrano, Begoña Acha, and Soledad Jiménez

    Arteriovenous Ratio Calculation Using Image-Processing Techniques

    Manuel G Penedo, Sonia González, Noelia Barreira, Marc Saez, Antonio Pose-Reino, and María Rodríguez-Blanco

    Survey on Techniques Used in Iris Recognition Systems

    Nagarajan Malmurugan, Shanmugam Selvamuthukumaran, and Sugadev Shanmugaprabha

    Formal Design and Development of an Anterior Segment Eye Disease Classification System

    Oliver Faust, Chan Wei Yan, Muthu Rama Krishnan Mookiah, U Rajendra Acharya, Eddie Y K Ng, and Wenwei Yu

    Modeling of Laser-Induced Thermal Damage to the Retina and the Cornea

    Mathieu Jean and Karl Schulmeister

    Automatization of Dry Eye Syndrome Tests

    Manuel G Penedo, Beatriz Remeseiro, Lucía Ramos, Noelia Barreira, Carlos García-Resúa, Eva Yebra-Pimentel, and Antonio Mosquera

    Thermal Modeling of the Ageing Eye

    Anastasios Papaioannou and Theodoros Samaras

    A Perspective Review on the Use of In Vivo Confocal Microscopy in the Ocular Surface

    Sze-Yee Lee, Andrea Petznick, Shakil Rehman, and Louis Tong

    Computational Modeling of Thermal Damage Induced by Laser in a Choroidal Melanoma

    José Duarte da Silva, Alcides Fernandes, Paulo Roberto Maciel Lyra, and Rita de Cássia Fernandes de Lima



    E Y K Ng, received his PhD at Cambridge University. He is a faculty member at the Nanyang Technological University in the School of Mechanical and Aerospace Engineering. Ng is editor-in-chief for the J. of Mechanics in Medicine and Biology and J. Med. Imaging and Health Informatics; assoc. editor for Int. J. of Rotating Machinery, Computational Fluid Dynamics J., Int. J. of Breast Cancer, Chinese J. of Medicine, Open Medical Informatics J., Open Numerical Methods J., and J. of Healthcare Engineering; and strategy assoc. editor-in-chief for World J. of Clinical Oncology. Ng has published more than 255 SCI journal papers, and co-edited 11 books including Human Eye Imaging and Modeling by CRC (2011).

    U. Rajendra Acharya, PhD, DEng is a visiting faculty in Ngee Ann Polytechnic, Singapore. He is also an adjunct professor at the University of Malaya, Malaysia; adjunct faculty in Singapore Institute of Technology-University of Glasgow, Singapore; associate faculty in SIM University, Singapore; and adjunct faculty in Manipal Institute of Technology, Manipal, India. He received his Ph.D. from the National Institute of Technology Karnataka, Surathkal, India and D Engg from Chiba University, Japan. He has published more than 275 papers in refereed international SCI-IF journals, international conference proceedings, textbook chapters, and books. His major interests are in biomedical signal processing, bio-imaging, data mining, visualization, and biophysics.

    Aurélio Campilho, is a full professor in the Department of Electrical and Computer Engineering, Faculty of Engineering, University of Porto (FEUP), Portugal. He served as president of the Biomedical Engineering Institute, as director of the doctoral program in Electrical and Computer Engineering at FEUP, and as a member of the Scientific Committee of the Master Degree in Bioengineering at the University of Porto. His current research interests include the areas of medical image analysis, image processing, and computer vision. He served as associate editor of the journals IEEE Transactions on Biomedical Engineering and of the Machine Vision Applications journal. He authored one book, co-edited 12 books, and published more than 150 papers in journals and conferences.

    Jasjit S. Suri, MS, PhD, MBA, Fellow AIMBE, has spent over 25 years in the field of biomedical engineering/sciences and its management. He received his masters from University of Illinois, Chicago, doctorate from University of Washington, Seattle, and executive management education from Weatherhead School of Management, Case Western Reserve University, Cleveland. Dr. Suri has written over 350 peer-reviewed publications, and is a committee member of several journals and companies. Dr. Suri was crowned with the President’s Gold medal in 1980 and the Fellow of American Institute of Medical and Biological Engineering (AIMBE), awarded by National Academy of Sciences, Washington DC in 2004.