Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail.
Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.
Table of Contents
Preface (Edythe D. London). Neurobiological Substrates Mediating the Reinforcing Effects of Psychomotor Stimulant and Opiate Drugs (Carol B. Hubner and George F. Koob). Receptor Autoradiography as Aid in Explaining Drug Action (Michael J. Kuhar and Errol B. De Souza). In Vitro Autoradiographic Studies of Drugs Acting at Dopamine Receptor Sites (James K. Wamsley and F. Filloux). Studies of Benzodiazepine Receptors Using In Vivo Autoradiography (Nick E. Goeders). CNS Receptors for Opiods (Richard J. Knapp, Mary Hunt, James K. Wamsley, and Henry I. Yamamura). Imaging Neuroreceptors to Study Drug Action in Living Human Brain (Dean F. Wong and Elias Shaya). Metabolic Mapping with Deoxyglucose Autoradiography as an Approach for Assessing Drug Action in the Central Nervous System (Akaeo Kurumaji, Deborah Dewar, and James McCulloch). Metabolic Mapping of the Effects of Psychomotor Stimulants (Linda J. Porrino and Francesco E. Pontieri). Positron Emission Tomographic Studies on the Acute Effects of Psychoactive Drugs on Brain Metabolism and Mood (Edythe D. London and Michael J. Morgan). Use of PET to Study Addiction in Humans (Nora Volkow and Joanna S. Fowler). Inter-rater Reliability in Positron Emission Tomography Image Analysis (William E. Semple, Jeannette L. Johnson, and Robert Cohen). Immunocytochemistry as a Strategy for Investigating the Functional Neuroanatomy of Drug Action in the Brain (Nathan M. Appel). In Situ Hybridization Histochemistry (Martin K.-H. Schafer, James P. Herman, and Stanley J. Watson). Identifying and Localizing Gene Expression Important for the Actions of Abused Drugs (George Uhl). Advanced Electrophysiological Imaging Techniques for Studying Drug Effects (Scott E. Lukas).