Immune Interferon: Properties and Clinical Applications, 1st Edition (Hardback) book cover

Immune Interferon

Properties and Clinical Applications, 1st Edition

By Roumen G. Tsanev, Ivan Ivanov

CRC Press

320 pages | 23 B/W Illus.

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Hardback: 9780849311482
pub: 2001-11-28
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pub: 2001-11-28
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Description

Now for the first time, one comprehensive book summarizes and analyzes the numerous scientific papers and reviews covering selected aspects of the structure, biological activities, and clinical effects of immune interferon, also known as interferon-gamma(IFN-gamma). Immune Interferon: Properties and Clinical Applications is essential reading for anyone working with interferons.

Having developed their own brand of interferon-gamma, the authors have become well known for their research and significant contributions in the fields of molecular biology, biochemistry, and interferon-gamma. They bring together the extensive findings from years of research since the discovery of the drug. Focusing on the drug itself and not particular brands, the book presents data on the properties of interferon-gamma, experimental data on its effects in cell cultures in vitro and on animals in vivo, the role that IFN-gamma plays in different diseases, and the results of its clinical applications.

As interest in this versatile drug continues to grow, new avenues for its clinical use will continue to arise. Within a single source, Immune Interferon: Properties and Clinical Applications provides you with thorough information on all facets of interferon-gamma, from biological properties, to pharmaceutical processing, to clinical application.

Reviews

"…an excellent review of indications studied and under study and the outcomes of IFNg, as well as an exhaustive collection of references for these indications. A briefer overview of the preclinical and pharmacologic aspects of IFNg is provided."

- James E. Talmidge, Ph.D., University of Nebraska Medical School in Doody's Notes

Table of Contents

FORWARD

ABBREVIATIONS

THE CYTOKINE FAMILY

INTERFERON GAMMA(IFNg)

Differences Between IFNg and IFN a/b

Interferon-Producing Cells. Inducers and Inhibitors. Effect of Aging

Structure and Physico-Chemical Properties of IFNg

Interferon Gamma Receptors

BIOLOGICAL ACTIVITIES OF INTERFERON GAMMA

Antiviral Activity

Antiproliferative Activity

Immunostimulatory Activity

Modulation of Gene Activity

Antibacterial Activity

Antitumor Activity

MOLECULAR MECHANISMS OF IFNg ACTIVITIES. TRANSMEMBRANE SIGNAL TRANSDUCTION

PRODUCTION OF INTERFERON GAMMA

GAMMA-INTERFERON PREPARATIONS

Interferon Gamma-1b

Gammaferon

Others

INDICATIONS AND CONTRAINDICTIONS

ROUTES OF ADMINISTRATION, PHARMACOKINETICS, DOSAGE

SIDE EFFECTS

INFECTIOUS DISEASES

Viral Infections

Herpes Simplex Type I and Type II

Herpes Zoster

Herpetic and Adenoviral Eye Infections

Respiratory Viral Infections

Human Papilloma Viruses (HPVs)

HIV Infection

Hepatitis

Non-Viral Intracellular Pathogens

Fungi

Non-Viral Extracellular Pathogens

NON-INFECTIOUS NON-MALIGNANT DISEASES

Fibroproliferative Diseases

Atherosclerosis

Multiple Sclerosis (MS)

Psoriasis

Chronic Granulomatous Disease (CGD)

Skin Ulcers in Autoimmune Vasculitis

Rheumatoid Arthritis (RA)

Osteopetrosis

Allergic Disorders

Lupus Erythematosus (SLE)

Heavy Traumas, Burns and Surgical Operations

MALIGNANT DISEASES

Background for Using IFNg in Malignancies

Basocellular Skin Cancer (Basalioma)

Cancer of the Larynx

Lung Cancer

Colorectal Cancer

Malignant Melanoma

Renal Cell Carcinoma (RCC)

Breast Cancer

Cervical Cancer

Gastric Cancer

Prostate Cancer

Ovarian Cancer

Cancer of the Bladder

Hepatocellular Carcinoma (HCC)

Sarcomas

Kaposi's Sarcoma

Neuroblastoma

Gliomas/Glyoblastomas

Hematologic Malignancies

Chronic Myelogenic Leukemia (CML)

B and T Chronic Lymphatic Leukemias (B-CLL and T-CLL)

Acute Leukemias

Lymphomas

Myelodisplastic Syndrome (MDS)

Multiple Myeloma (MM)

Conclusions on the Use of IFN-g In Malignant Diseases

GENERAL CONCLUSIONS

REFERENCES

About the Series

Pharmacology and Toxicology: Basic and Clinical Aspects

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology