This book presents an overview of the pathogenesis of allergic contact dermatitis (ACD). It explains the characterization of T cell subsets which modulate immune reaction to chemicals and may represent a formidable tool for new therapeutic approaches to ACD and other T cell-mediated skin disorders.
Table of Contents
1. Approaches to the Predictive Identification and Assessment of Chemical Contact Allergens 2. Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the Recepto 3. Langerhans Cell Migration and the Induction Phase of Skin Sensitization 4. Contribution of CD4' and CD8' T Cells in Contact Hypersensitivity and Allergic Contact Dermatitis 5. T Cell Subsets in Allergic Contact Dermatitis 6. T Cell Recruitment in Allergic Contact Dermatitis 7. Cytokines in Contact Sensitivity 8. The Use of Gene-Targeted Mice in Contact Hypersensitivity Research 9. A Dual Role for Mast Cells in Contact Hypersensitivity Reactions: More Team Players in Type 1 T Cell Mediated Contact Hypersensitivity Reactions 10. Multiple Roles of Keratinocytes in Allergic Contact Dermatitis 11. UVB Radiation and Modulation of T Cell Responses to Haptens 12. Dendritic Cells as a Target for Therapeutic Intervention of Contact Hypersensitivity 13. Evidence-Based Answers to Clinical Questions in Allergic Contact Dermatitis