The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies. It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influencing the interaction of many different immune cells in the body. Citing current experimental trials, it examines the role and pathology of T-cells and suggests additional experimental approaches to the problem.
Table of Contents
Which cells control the anti-cancer T cell immune response?
T cells and cancer cells: Components of immune-based anti-cancer therapy
Anti-cancer vaccines: New approaches
How and why do we get cancer and can immune-based anti-cancer therapy save us?
Immunotherapeutic approaches to the treatment of leukemia
Cancer stem cell: Can we solve the cancer stem cell program and cure cancer using T cell-based immunotherapy?
Translational immunology and its impact on anti-cancer T cell immunity and the development of immuno-therapeutic treatments for cancer
Dendritic cells, immunotherapy and the anti-cancer T cell response
Regulatory T cells and dendritic cells and the success of immunotherapeutic treatments for cancer
NK cells and their role in the development of immune-based anti-cancer therapy
How cancer cells influence the anti-cancer T cell response and why this is a problem during the immunotherapeutic treatment of cancer
The T cell anti-cancer response, T cell regulation and immunotherapy of neural crest cancers
The immunological hole: Will we fall in?
Summary and concluding remarks
Alexander\, Michael A.