1st Edition

Immunomodulators in Aquaculture and Fish Health

Edited By Preetham Elumalai, Mehdi Soltani, Sreeja Lakshmi Copyright 2024
    282 Pages 45 B/W Illustrations
    by CRC Press

    This reference book provides updated information about different immunomodulators for managing fish health and sustainable aquaculture. Immunomodulators are dietary additives that enhance innate defense mechanisms and increase resistance against specific pathogens and diseases. The book covers the different types of immunostimulants, their modes of action, and their efficacies. It also reviews safety concerns, ethical regulations, limitations, and outreach to farmers. It discusses the application of herbal immunomodulators, antioxidants, pre- and pro-biotics, in disease management.


    • Reviews the pressing topic of reduction of antibiotic use in aquaculture
    • Discusses herbal immunomodulators, nutrients, antioxidants and pre- and pro-biotics
    • Covers the topic of progressive immunomodulation using nanotechnology
    • Discusses fish health management in the ever-growing aquaculture industry
    • Includes natural and synthetic immunomodulators

    The book is meant for researchers and industry experts in aquaculture, fisheries science, and veterinary medicine.

    Section I: Immunomodulators: An Overview

    1. Immunomodulators: An Introduction
    Falco F, Banaee M, Mauro M, Faggio C, Arathi Kollath, Sujitha Mullekkattu, and Preetham Elumalai

    2. Natural and Synthetic Immunomodulators: Inferences for Stress Responses in Aquaculture Fish
    Shubhajit Saha, Azubuike V. Chukwuka, Nimai Chandra Saha, Caterina Faggio, and Hamed Mousavi Sabet

    3. Immunomodulators: Mode of Action
    Subramaniam Sivakumar, C. Shanmuga Sundaram, Maderi Velayutham Dassprakash, and Rantham Subramaniam Venkatesan

    4. Immunomodulator and Stress Oxidative
    Tamilselvan Gokul, Paulraj Balaji, Karthikeyan Venkatachalam, Subramanian Ramya, Ramaraj Jayakumararaj, Chinnathambi Pothiraj, and Kamatchi Ramesh Kumar

    Section II: Immunomodulators and Sustainable Aquaculture Development 

    5. Immunomodulators to Prevent Diseases and Minimize Antimicrobial Use
    Akshay Thuruthiyil Rajesh, Sajna Beegum, Neha Omgy, Sreeja Lakshmi, Hethesh Chellapandian, Sivakamavalli Jeyachandran, Einar Ringø, and Preetham Elumalai
    6. Immunomodulation in Aquaculture Health Management: Opportunities and Obstacles
    Ramchandran Ishwarya, Baskaralingam Vaseeharan, Rengarajan  Jayakumar,  Subramaniam Sivakumar, and Preetham Elumalai

    7. Disease Management and Prophylaxis by Immunostimulants
    Chinnathambi Pothiraj, Divya Jyoti, Subramanian Ramya, Ramaraj Jayakumararaj, Aseem Grover, Reshma Sinha, Palanichamy Ayyappan, Caterina Faggio, and Paulraj Balaji

    8. Application of Immunostimulants for Aquaculture Health Management
    Femi John Fawole, Shamna Nazeemashahul, Thongam Ibemcha Chanu, Arun Sharma, Gbadamosi Oluyemi Kazeem, S. Ferosekhan, and Tejaswini Kinnera

    Section III: Immunomodulators in Aquaculture Health Management

    9. Herbal Immunomodulators for Aquaculture
    Shamna Nazeemashahul, Fawole Femi John, Babitha Rani A.M., Manish Jayant, Neha Qureshi, Hussain Nottanalan, Ashutosh D Deo, and Parimal Sardar

    10. Prebiotics and Probiotics as Effective Immunomodulators in Aquaculture
    Mehdi Soltani, Koushik Ghosh, Dipanjan Dutta, and Einar Ringø

    11. Immunomodulation in Fish Through Nutrients, Antioxidants and Hormones
    Chiranjiv Pradhan, Nikhila Peter, and Sweta Das
    12. Cytokines and Fish Health
    Aifa Fathima, Yaser Arafath, Saqib Hassan, George Seghal Kiran, and Joseph Selvin

    13. Progressive Immunomodulation Through Nanotechnology
    Heba Mahboub, Hiam Elabd, Mian Adnan Kakakhel, Gehad E. Elshopakey, Maram H. Abduljabbar, Manal E. Alosaimi

    Section IV: Current Status of Immunomodulators in Aquaculture

    14. Efficacy and Limitations of Immunomodulators
    Arathi Kollath, Lokesh Pawar, Ankeet Bhagat, Sunil Sharma, Owias Iqbal Dar, and Preetham Elumalai

    15. Current Status/Recent Advancements with Immunostimulants in Aquaculture
    Parasuraman Aiya Subramani, S. Kalaivani Priyadarshini, Ramalakshmi Balasubramanian, M. Divya Gnaneswari, Devasree Ganesh Kumar, Priyatharsini Rajendran, Catherine Alexander, and R. Dinakaran Michael



    Preetham Elumalai, PhD, is an Associate Professor at the Department of Marine Biology, Cochin University of Science and Technology, Kochi, Kerala, India. He earned a Master’s degree from the University of Madras and a PhD in biochemistry and molecular immunology from the Institute for Immunology, University of Regensburg, Germany. His research practice includes bioassay-guided identification of novel marine compounds, unveiling fish lectins in innate immune defense, aquatic vaccine development, evaluation of cost-effective feed additives and nutrigenomics, and effects of environmental pollutants on marine ecosystems. He has been a partner in numerous EU-, Indian-,and UK-funded projects (e.g., IVVN, BactiVac). He has written more than 70 peer-reviewed articles and has 2 patents in his name apart from editing 5 books (Springer, CRC Press) and has presented his work at more than 60 national and international conferences. He has been awarded the prestigious INSA fellowship (2018); MASTS, Fellowship (2019); IVVN award, UK (2020); FRSB award (2021); and BactiVac award, UK (2022).

    Mehdi Soltani, PhD, is a distinguished professor at university of Tehran and an adjunct professor at Murdoch University, Australia. He earned a DVM from university of Tehran and PhD in aquatic animal health from university of Tasmania, Australia. Professor Soltani has an international reputation for research on aquatic animal health, with 290 published scientific papers, collaborations with researchers throughout the world and editorship of scientific journals in fisheries and veterinary science. He chaired government advisory committees in fisheries and aquaculture and have also worked closely with the aquaculture industry. He developed and patented a number of fish vaccines, which are registered throughout the Middle East. He also taught numerous undergraduate courses and supervised many higher degree students. His research interests include vaccine development for fish pathogens, immunopathogenesis of infectious agents in fish/shellfish and development of alternative therapies such as immunostimulants, probiotics and phytobiotics for disease control in farmed fish and shellfish.

    Sreeja Lakshmi, PhD, is a Postdoctoral Research Scientist in collaboration with Moredun Research Institute (MRI), UK. She graduated from Calicut University and earned a PhD in biochemistry and functional genomics from the Institute for Molecular Biology, University of Regensburg, Germany. She has published research articles in peer-reviewed international journals and authored books and book chapters. She has been awarded prestigious research grants from the Bavarian Research Foundation (Bayerische Forschungsstiftung), Government of Bavaria, Germany; an HRD-Fellowship for Women Scientists from the Department of Health Research, Government of India; and a MASTS (Marine Alliance Science and Technology, Scotland) Award for Postdoctoral and Early Career Research Exchanges (PECRE), visited the University of Aberdeen, Scotland, and received IVVN Fellowship grant from the International Veterinary Vaccinology Network (IVVN), UK.