1st Edition

Induced Effects Of Genotoxic Agents In Eukaryotic Cells

Edited By

Toby G Rossman




ISBN 9781560322726
Published September 21, 1992 by CRC Press
167 Pages

USD $220.00

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Book Description

This book provides an understanding of the consequences of induced proteins in the toxicological response of cells to chemical and radiation damage to DNA and will be helpful in creating proper mathematical models for extrapolation to low doses and assessing human exposure or cellular injury.

Table of Contents

Xenobiotic Regulation Of Glutathione S-Transferase Ya Gene Expression; induction of a novel damage-specific DNA binding protein correlates with enhanced DNA repair in primate cells; repair of alkylated bases in mammalian cells; modulation in response to DNA-damaging agents; modification in DNA ligase activity during DNA repair in mammalian cells; Cell-Cycle And DNA-Damage Regulation Of Ribonucleotide Reductase In saccharomyces cerevisiae; review - gene amplification - a cellular response to genotoxic stress; carcinogen-inducible proteins as mediators of asynchronous replication of DNA tumor viruses; carcinogen-induced gene amplification and gene expression; gadd153, a growth arrest and DNA- damage-induced gene - expression in response to genotoxic stress; ultraviolet irradiation and phorbol esters induce gene transcription by different mechanisms. Part contents.

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