1st Edition

Industrialization of Drug Discovery From Target Selection Through Lead Optimization

Edited By Ph.D. Handen Copyright 2005
324 Pages 39 B/W Illustrations
by CRC Press

328 Pages 39 B/W Illustrations
by CRC Press

328 Pages
by CRC Press

The drug discovery and development process is getting longer, more expensive, and no better. The industry suffers from the same clinical attrition and safety-related market withdrawal rates today as it did 20 years ago. Industrialization of Drug Discovery: From Target Selection Through Lead Optimization scrutinizes these problems in detail, contrasting the promise of technology and... Read more
Drug Discovery in the Modern Age: How We Got Here and Where Do We Go?. The Regulatory Age. Industrialization Not Automation. Compound Management. High Throughput Screening. Parallel Lead Optimization. Knowledge Management. ROI – How to Measure It? How to Get It?. Collaboration in a Virtual and Global Environment. From Genome to Drug: Ethical Issues.

Biography

Jeffrey S. Handen, Ph.D.

“The book comprises of 10 well-defined chapters. Detailed discussion on historical background to drug discovery in modern age consists of basic concepts, how they have evolved and various approaches and strategies in modern drug discovery. … The book provides a very good review on all aspects of industrialization of drug discovery. … the book is of particular interest since it gives a systematic and in depth account of related topics to transform research into industrialization. This is a very good book of relevance to anyone interested in drug discovery and more, so for all personnel working in drug discovery.”
—K. S. Laddha, Reader in Pharmacognosy, University Institute of Chemical Technology, Mumbai, in Chemical Industry Digest, February 2007

"Chapter 4, the best part of the book, is an extensive and excellent discussion of aspects of compound- library management. The authors of this chapter have considered all basic aspects of this important component of drug discovery . . . well written with extensive references."

– Robert Goodnow, Hoffmann-LaRoche, in ChemMedChem, 2006, No. 3