Inflammatory Mechanisms in Asthma: 1st Edition (Hardback) book cover

Inflammatory Mechanisms in Asthma

1st Edition

Edited by Stephen Holgate

CRC Press

1,090 pages

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Hardback: 9780824701222
pub: 1998-05-27
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pub: 2018-12-07
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This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies.

Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma

  • describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis

  • reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages

  • considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations

  • presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis

  • and more!

    Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

  • Table of Contents

    The Pathology of Fatal Asthma, Alan L. James and Neil Carroll

    Bronchoscopy, Anthony J. Frew and Ratko DjukanovicM

    Bronchoalveolar Lavage in Studies of Asthma, Mark C. Liu and William J. Calhoun

    Evidence from Induced Sputum, Peter G. Gibson and Frederick E. Hargreave

    Mast Cell Proteases in Asthma, Andrew F. Walls

    Mast Cell Cytokines in Allergic Inflammation, John Joseph Costa, Stephen J. Galli, and Martin K. Church

    Airway Responses to Antigen in Asthmatic and Nonasthmatic Subjects, Stephen P. Peters, Joseph R. Shaver, James G. Zangrilli, and James E. Fish

    The Role of the Basophil in the Inflammatory Mechanisms of Asthma, L. H. Thomas and J. A. Warner

    Eosinophils: Granule Proteins, María-Cristina Seminario, Cheryl R. Adolphson, and Gerald J. Gleich

    Eosinophil Activation in Asthma, Shinji Motojima, Takeshi Fukuda, and Sohei Makino

    Eosinophil Autacoids, Anthony P. Sampson

    Eosinophil Cytokines, Redwan Moqbel and Paige Lacy

    Eosinophils in Asthma, Aparna Kumar and William W. Busse

    Interactions Between Eosinophils and the Airway Epithelium, Clive Robinson and Julia E. Carver

    Neutrophils and Asthma, L. Fabbri, Piera Boschetto, G. Caramori, and P. Maestrelli

    Allergen Recognition Sites in Immunoglobulin E from Patients with Asthma, Rachel E. Snow, Caroline J. Chapman, and Freda K. Stevenson

    T Cells in Asthma, Chris J. Corrigan

    Macrophages and Macrophage Diversity in Asthma, Shoobha S. Daftary, William J. Calhoun, and Nizar N. Jarjour

    Antigen Presentation in the Asthmatic Lung, Jonathan D. Edgeworth, Tak H. Lee, and Vanya Alasdair Gant

    Macrophage and Dendritic Cell Populations in Airway Tissues, Patrick G. Holt and Andrew S. McWilliam

    Fibroblasts and the Extracellular Matrix in Asthma, Anthony E. Redington, Patricia J. Sime, Peter H. Howarth, and Stephen T. Holgate

    Mediator Functions of Epithelial Cells, Katharine Knobil and David B. Jacoby

    Epithelium as a Target, Steven R. White and Alan R. Leff

    Airway Neuropeptides and Their Role in Inflammation, Peter J. Barnes

    Neuroimmune Interactions in Airway Inflammation, Karen E. Pedersen, Allen C. Myers, and Bradley J. Undem

    Microvascular-Epithelial Exudation of Bulk Plasma in Airway Defense, Disease, and Repair, Carl G. A. Persson, J. S. Erjefält, M. Andersson, L. Greiff, and C. Svensson

    Neuroregulation of Mucosal Vasculature, James N. Baraniuk and Howard M. Druce

    Leukocyte-Endothelial Adhesion, Frank P. Bell, Brydon L. Bennett, and Anthony M. Manning

    Prostanoids, Arthur N. Freed and Steven R. Kleeberger

    Leukotrienes, Sven-Erik Dahlén

    Adenosine: Its Contribution to Our Understanding of Asthma, Gerrard D. Phillips and Stephen T. Holgate

    Chemotaxis and Mechanisms of Cell Migration, Janis K. Shute and Rabiâ Hidi

    Kinins, Bruce L. Zuraw and Sandra C. Christiansen

    The Early and Late Asthmatic Response to Allergen, Ketan K. Sheth and Robert F. Lemanske, Jr.

    Inflammatory Mechanisms of Aspirin-Sensitive Asthma, S. M. Shuaib Nasser and Tak H. Lee

    Inflammatory Mechanisms in Nocturnal Asthma, George C. Georges and Richard J. Martin

    Inflammatory Mediators and Exercise-Induced Asthma, Sandra D. Anderson

    Mechanisms of Airway Hyperresponsiveness, Paul M. O'Byrne

    Transcription Factors as Activators and Repressors of Gene Transcription: NK-RB and Glucocorticoid Receptors, Ian M. Adcock and Robert Newton

    Lower Airway Responses to Viruses, Philip G. Bardin, David J. Fraenkel, and Philip J. Bates

    About the Series

    Lung Biology in Health and Disease

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    Subject Categories

    BISAC Subject Codes/Headings:
    MEDICAL / Clinical Medicine
    MEDICAL / Pulmonary & Thoracic Medicine