1st Edition

Inflammatory Mechanisms in Asthma

Edited By Stephen Holgate Copyright 1998

    This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies.
    Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma

  • describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis
  • reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages
  • considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations
  • presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis
  • and more!
    Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.
  • The Pathology of Fatal Asthma, Alan L. James and Neil Carroll
    Bronchoscopy, Anthony J. Frew and Ratko DjukanovicM
    Bronchoalveolar Lavage in Studies of Asthma, Mark C. Liu and William J. Calhoun
    Evidence from Induced Sputum, Peter G. Gibson and Frederick E. Hargreave
    Mast Cell Proteases in Asthma, Andrew F. Walls
    Mast Cell Cytokines in Allergic Inflammation, John Joseph Costa, Stephen J. Galli, and Martin K. Church
    Airway Responses to Antigen in Asthmatic and Nonasthmatic Subjects, Stephen P. Peters, Joseph R. Shaver, James G. Zangrilli, and James E. Fish
    The Role of the Basophil in the Inflammatory Mechanisms of Asthma, L. H. Thomas and J. A. Warner
    Eosinophils: Granule Proteins, María-Cristina Seminario, Cheryl R. Adolphson, and Gerald J. Gleich
    Eosinophil Activation in Asthma, Shinji Motojima, Takeshi Fukuda, and Sohei Makino
    Eosinophil Autacoids, Anthony P. Sampson
    Eosinophil Cytokines, Redwan Moqbel and Paige Lacy
    Eosinophils in Asthma, Aparna Kumar and William W. Busse
    Interactions Between Eosinophils and the Airway Epithelium, Clive Robinson and Julia E. Carver
    Neutrophils and Asthma, L. Fabbri, Piera Boschetto, G. Caramori, and P. Maestrelli
    Allergen Recognition Sites in Immunoglobulin E from Patients with Asthma, Rachel E. Snow, Caroline J. Chapman, and Freda K. Stevenson
    T Cells in Asthma, Chris J. Corrigan
    Macrophages and Macrophage Diversity in Asthma, Shoobha S. Daftary, William J. Calhoun, and Nizar N. Jarjour
    Antigen Presentation in the Asthmatic Lung, Jonathan D. Edgeworth, Tak H. Lee, and Vanya Alasdair Gant
    Macrophage and Dendritic Cell Populations in Airway Tissues, Patrick G. Holt and Andrew S. McWilliam
    Fibroblasts and the Extracellular Matrix in Asthma, Anthony E. Redington, Patricia J. Sime, Peter H. Howarth, and Stephen T. Holgate
    Mediator Functions of Epithelial Cells, Katharine Knobil and David B. Jacoby
    Epithelium as a Target, Steven R. White and Alan R. Leff
    Airway Neuropeptides and Their Role in Inflammation, Peter J. Barnes
    Neuroimmune Interactions in Airway Inflammation, Karen E. Pedersen, Allen C. Myers, and Bradley J. Undem
    Microvascular-Epithelial Exudation of Bulk Plasma in Airway Defense, Disease, and Repair, Carl G. A. Persson, J. S. Erjefält, M. Andersson, L. Greiff, and C. Svensson
    Neuroregulation of Mucosal Vasculature, James N. Baraniuk and Howard M. Druce
    Leukocyte-Endothelial Adhesion, Frank P. Bell, Brydon L. Bennett, and Anthony M. Manning
    Prostanoids, Arthur N. Freed and Steven R. Kleeberger
    Leukotrienes, Sven-Erik Dahlén
    Adenosine: Its Contribution to Our Understanding of Asthma, Gerrard D. Phillips and Stephen T. Holgate
    Chemotaxis and Mechanisms of Cell Migration, Janis K. Shute and Rabiâ Hidi
    Kinins, Bruce L. Zuraw and Sandra C. Christiansen
    The Early and Late Asthmatic Response to Allergen, Ketan K. Sheth and Robert F. Lemanske, Jr.
    Inflammatory Mechanisms of Aspirin-Sensitive Asthma, S. M. Shuaib Nasser and Tak H. Lee
    Inflammatory Mechanisms in Nocturnal Asthma, George C. Georges and Richard J. Martin
    Inflammatory Mediators and Exercise-Induced Asthma, Sandra D. Anderson
    Mechanisms of Airway Hyperresponsiveness, Paul M. O'Byrne
    Transcription Factors as Activators and Repressors of Gene Transcription: NK-RB and Glucocorticoid Receptors, Ian M. Adcock and Robert Newton
    Lower Airway Responses to Viruses, Philip G. Bardin, David J. Fraenkel, and Philip J. Bates


    Stephen Holgate