Inhalation Toxicology: 3rd Edition (Paperback) book cover

Inhalation Toxicology

3rd Edition

Edited by Harry Salem, Sidney A. Katz

CRC Press

623 pages | 16 Color Illus. | 152 B/W Illus.

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Description

The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the body through the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoveries since the last edition, Inhalation Toxicology, Third Edition presents contributions from internationally recognized scientists in the academic, commercial/industrial, and governmental sectors. A pragmatic resource for practicing professionals and students, the book comprehensively examines the relationship between the respiratory system and the toxicology of inhaled substances.

Topics include:

  • Regulatory aspects of exposure and testing
  • Testing equipment and procedures
  • Respiratory allergy and irritation of the respiratory tract
  • Risk assessment
  • Toxicology theory
  • Toxicology modeling
  • Toxic effects of some individual toxicants

New topics in this third edition include collection and characterization of airborne particulate matter, the inhalation toxicology of asbestos fibers and nanoparticles, and the development of lung-on-a-chip technology for predicting in vivo responses. Each chapter concludes with thought-provoking questions and answers, enhancing the book’s educational utility.

Reviews

"The editors' thoughtful treatment is absolutely stunning as is their capacity to guide authors toward creative, comprehensive entries while also maintaining a degree of uniformity among topics … Inhalation Toxicology has been a standard reference and textbook for respiratory scientists."

—J. Thomas Pierce, PhD, Navy Environmental Health Center, in Doody’s Review Service

Table of Contents

Inhalation Methods and Measurements

Inhalation Risk Assessment at the Environmental Protection Agency

The Development and Application of Acute Exposure Guideline Levels for Hazardous Substances

Emergency Response Planning Guidelines (ERPGs)

Directed Flow Aerosol Inhalation Exposure Systems: Application to Pathogens and Highly Toxic Agents

Whole-Body, Low-Level Sarin Vapor Exposure in Rats: Estimating the Probability of Miosis as a Function of Exposure Concentration and Duration

Application of Intratracheal Instillation Exposure to the Etiological Determination of a Pulmonary Disease Outbreak: Nylon Flock as an Example

The Use of Large Animals in Inhalation Toxicology

Toxic Load Modeling

Inhalation Toxicology and Carcinogenicity Studies of the National Toxicology Program

Combustion Toxicology

Inhalation Toxicology Mechanisms

Toxicogenomics of Low-Level Nerve Agent Vapor Exposure

Respiratory Sensitization

Peripheral Chemosensory Irritation with Particular Reference to Respiratory Tract Exposure

Role of Cytokines in Pulmonary Inflammation and Fibrosis Induced by Inhaled Mineral Particles

Hormesis: Implications for Risk Assessment

Nasal Toxicology

Effects of Inhaled Toxicants on the Nose and Nasal Function

Toxicokinetics: Deposition, Absorption, Distribution, and Excretion

Inhalation Toxicology of an Irritant Gas: Historical Perspectives, Current Research, and Case Studies of Phosgene Exposure

Inhalation Toxicology of Riot Control Agents

Chemical Warfare Agents and Nuclear Weapons

Inhalation Toxicology of Metals (Chromium)

Safety Assessment of Therapeutic Agents Administered by the Inhalation Route

Nonclinical Pharmacology and Safety Studies of Insulin Administered to the Respiratory Tract

Inhalation Toxicology of Materials

Inhalation Toxicology of Alcohol/Gasoline Fuels: Current Status

Asbestos

The Inhalation Toxicity of Benzene

Carbon Monoxide

Experimental, Clinical, Occupational Toxicology and Forensic Aspects of Hydrogen Cyanide and Particular Reference to Vapor Exposure

The Pharmacology and Toxicology of Inhaled Dusts, Endotoxins, and Glucans

Fluorocarbon Alternatives: Methodologies for Special Studies and Results

Animal Models for Three Major Cigarette-Smoke-Induced Diseases

The Impact of Active and Passive Exposure to Cigarette Smoke on Maternal and Fetal Health

Inhalation Toxicology of Biologicals

Health Aspects of Bioaerosols

Emerging Biothreats: Natural and Deliberate

Toxicology Associated with Respiratory Exposures to Fungi (Molds)

Inhalation of Botulinum Toxins

Inhalation of Ricin: Aerosol Procedures, Animal Toxicology, and Therapy

Inhalation Toxicology & Pharmacology of Biologicals and Toxins: Prophylaxis and Therapy

About the Editors

Harry Salemis the Chief Scientist at the U.S. Army Edgewood Chemical Biological Center. He has been a visiting professor at Drexel University, Rutgers University, Temple University, and the University of Pennsylvania and he has held a variety of positions in the pharmaceutical industry and in commercial toxicology laboratories. He was the editor-in-chief of the Journal of Applied Toxicology and is on the editorial board of the Journal of Inhalation Toxicology. He was the 2001 Society of Toxicology Congressional Science Fellow, and is a Fellow of the New York Academy of Sciences, the American College of Clinical Pharmacology, the American College of Toxicology, and the Academy of Toxicological Sciences.

Sidney A. Katzis a professor of chemistry at Rutgers University. He has been a visiting professor in Canada, England, Germany, Hungary, Slovenia, and South Africa and has held research positions with E.I. duPont de Nemours and Company and with the R.M. Hollingshead Corporation. He has been a research fellow at the U.S. Army Edgewood Chemical Biological Center. His research activity is in environmental bioanalytical chemistry. From 1997 to 2002, he was a New Jersey commissioner for hazardous waste facilities siting.

Subject Categories

BISAC Subject Codes/Headings:
MED079000
MEDICAL / Pulmonary & Thoracic Medicine
MED096000
MEDICAL / Toxicology
SCI026000
SCIENCE / Environmental Science