Inhaled therapies form the cornerstone for treatment of patients with asthma and COPD. Evolving technology has resulted in availability of a wide range of devices for delivery of inhaled drugs. The four different delivery systems -- pressurized metered-dose inhalers, slow mist inhalers, dry powder inhalers, and nebulizers -- are unique in design and require distinct inhalational instructions for correct use. This book provides current information about inhalation devices, including their advantages and disadvantages, with guidance for optimal techniques of use. The book emphasizes appropriate selection of inhalation devices based on patient and health care professional factors as well as device attributes that allow selection of the right medication in the right inhalation device at the right time for the right patient.
• Addresses the objective of precision medicine – the right medication in the right inhaler device at the right time.
• Inputs by international thought leaders who have published widely on inhaled medications and/or inhaled delivery systems for clinicians, trainees and respiratory therapists.
• Discusses the development of audio-based systems and smart inhalers for patient monitoring.
About the Editors
List of Contributors
1. Principles of Inhaled Therapy
Omar S. Usmani and Federico Lavorini
2. Goals of Pharmacotherapy for Asthma and COPD
Donald A. Mahler and Marc Miravitlles
3. Pressurized Metered-Dose Inhalers (pMDI)
Donna D. Gardner and Sandra G. Adams
4. Spacers and Valved Holding Chambers
Rajiv Dhand and Myrna B. Dolovich
5. Slow Mist Inhalers
P.N. Richard Dekhuijzen, Matteo Bonini and Federico Lavorini
6. Dry Powder Inhalers
Donald A. Mahler and Roy A. Pleasants
7. Digital Inhalers for the Management of Obstructive Lung Diseases
Roy A. Pleasants and Stephen L. Tilley
Paul D. Terry and Rajiv Dhand
9. Inhalation Therapy in Infants and Children
Bruce K. Rubin, Israel Amirav
10. Selection of Inhaler Delivery System for Adult Outpatients
David M. G. Halpin and P. N. Richard Dekhuijzen
11. Inhalation Therapy in the Intensive Care Unit
Jie Li and Rajiv Dhand
12. Inhaled Therapy for Other Respiratory Diseases: Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis
Mahmoud Ibrahim and Alexander G. Duarte
13. Inhaled Therapy for Other Respiratory Diseases: Pulmonary Hypertension
Isaac N. Biney and Francisco J. Soto
14. Regulatory Considerations Related to Inhaled Delivery Systems
Lydia I. Gilbert-McClain