1st Edition

Inhaled Delivery Systems for the Treatment of Asthma and COPD

Edited By Donald A. Mahler, Rajiv Dhand Copyright 2023
    208 Pages 37 Color & 5 B/W Illustrations
    by CRC Press

    208 Pages 37 Color & 5 B/W Illustrations
    by CRC Press

    208 Pages 37 Color & 5 B/W Illustrations
    by CRC Press

    Inhaled therapies form the cornerstone for treatment of patients with asthma and COPD. Evolving technology has resulted in availability of a wide range of devices for delivery of inhaled drugs. The four different delivery systems -- pressurized metered-dose inhalers, slow mist inhalers, dry powder inhalers, and nebulizers -- are unique in design and require distinct inhalational instructions for correct use. This book provides current information about inhalation devices, including their advantages and disadvantages, with guidance for optimal techniques of use. The book emphasizes appropriate selection of inhalation devices based on patient and health care professional factors as well as device attributes that allow selection of the right medication in the right inhalation device at the right time for the right patient.

    Key Features:
    • Addresses the objective of precision medicine – the right medication in the right inhaler device at the right time.
    • Inputs by international thought leaders who have published widely on inhaled medications and/or inhaled delivery systems for clinicians, trainees and respiratory therapists.
    • Discusses the development of audio-based systems and smart inhalers for patient monitoring.


    About the Editors

    List of Contributors


    1. Principles of Inhaled Therapy

    Omar S. Usmani and Federico Lavorini

    2. Goals of Pharmacotherapy for Asthma and COPD

    Donald A. Mahler and Marc Miravitlles

    3. Pressurized Metered-Dose Inhalers (pMDI)

    Donna D. Gardner and Sandra G. Adams

    4. Spacers and Valved Holding Chambers

    Rajiv Dhand and Myrna B. Dolovich

    5. Slow Mist Inhalers

    P.N. Richard Dekhuijzen, Matteo Bonini and Federico Lavorini

    6. Dry Powder Inhalers

    Donald A. Mahler and Roy A. Pleasants

    7. Digital Inhalers for the Management of Obstructive Lung Diseases

    Roy A. Pleasants and Stephen L. Tilley

    8. Nebulizers

    Paul D. Terry and Rajiv Dhand

    9. Inhalation Therapy in Infants and Children

    Bruce K. Rubin, Israel Amirav

    10. Selection of Inhaler Delivery System for Adult Outpatients

    David M. G. Halpin and P. N. Richard Dekhuijzen

    11. Inhalation Therapy in the Intensive Care Unit

    Jie Li and Rajiv Dhand

    12. Inhaled Therapy for Other Respiratory Diseases: Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis

    Mahmoud Ibrahim and Alexander G. Duarte

    13. Inhaled Therapy for Other Respiratory Diseases: Pulmonary Hypertension

    Isaac N. Biney and Francisco J. Soto

    14. Regulatory Considerations Related to Inhaled Delivery Systems

    Lydia I. Gilbert-McClain



    Dr. Donald A. Mahler, M.D., is Emeritus Professor of Medicine at Geisel School of Medicine at Dartmouth in Hanover, New Hampshire. He currently works as a pulmonary physician at Valley Regional Hospital in Claremont, New Hampshire, where he is Director of Respiratory Services.

    Dr. Rajiv Dhand serves as Professor of Medicine with tenure, the Wahid T. Hanna, MD Endowed Chair of the Department of Medicine, Service Chief of the Medical Service and Associate Dean of Clinical Affairs at the University of Tennessee, Graduate School of Medicine in Knoxville, TN.