Inhaled Steroids in Asthma : Optimizing Effects in the Airways book cover
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Inhaled Steroids in Asthma
Optimizing Effects in the Airways




ISBN 9780824705855
Published November 21, 2001 by CRC Press
760 Pages

 
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Book Description

This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development.
Makes connections among the underlying pharmacology, impact of new simulation models, newly recognized molecular targets, and therapeutic outcomes of short- and long-term steroid inhalation therapy!
Containing more than 1600 works cited, drawings, tables, equations, and micrographs, Inhaled Steroids in Asthma

  • describes the developmental history of inhaled steroids and provides general models for lung selectivity
  • considers the best way to select inhaled steroids
  • clarifies local metabolism, airway and lung uptake and retention, and other determinants of once-daily usage
  • addresses variations in lung deposition and total bioavailability among available steroids and formulations
  • surveys the dynamics of receptor gene-mediated processes
  • analyzes the role of chemokines in airway allergic inflammatory diseases
  • discusses the effects of inhaled steroids in vivo on cell progenitors in asthma and rhinitis
  • details measuring airway inflammation as a guide for treatment decisions
  • outlines the clinical relevancy of exhaled nitric oxide in asthma
  • covers optimal trial design for judging antiasthmatic potency and efficacy
  • evaluates the safety of inhaled steroids
    Written by more than 40 of the world's leading authorities and investigators, Inhaled Steroids in Asthma is an authoritative reference for pulmonologists and pulmonary disease specialists; physiologists; allergists; immunologists; molecular, cell, and lung biologists; pediatricians; pharmaceutical scientists and pharmacologists; and medical school and upper-level undergraduate, graduate, and medical school students in these disciplines.
  • Table of Contents

    INTRODUCTON
    Drug Development of Inhaled Steroids: A Pharmacologist's View Based on Experiences from the Budesonide Project
    Ralph Brattsand

    Part Two USE OF INHALED STEROIDS
    How Inhaled Corticosteroids Changed Asthma Therapy
    William W. Busse
    Side Effects of Inhaled Corticosteroids
    Paul M. O'Byrne and Dilini Vethanayagam

    Part Three MOLECULAR ASPECTS OF STEROID ACTION
    Mechanisms of Gene Regulation by the Glucocorticoid Receptor
    Gary B. Faulds, Nanthakumar Subramaniam, Johan Lidén, and Sam Okret
    Relationship of Dose- and Time-Dependent Corticosteroid Responses to Receptor Turnover
    William J. Jusko
    Blockade of Chemokine Production/Function as an Example of Glucocorticoid Anti-inflammatory Actions
    Cristiana Stellato
    Newly Recognized Glucocorticoid Targets
    Nicola M. Heller and Robert P. Schleimer

    Part Four DETERMINANT S OF AIRWAY-LUNG SELECTIVITY
    Aerosol Delivery Devices and Airways/Lung Deposition
    Myrna B. Dolovich
    Uptake, Retention, and Biotransformation of Corticosteroids in the Lung and Airways
    Staffan Edsbäcker
    Systemic Disposition and Effects of Inhaled Corticosteroids
    Hartmut Derendorf, Sriram Krishnaswami, Gunther Hochhaus, and Helmut Möllmann
    Extrapulmonary Effects of Inhaled Corticosteroids
    Judah A. Denburg, Mark D. Inman, Roma Sehmi, Lorna J. Wood, Gail M. Gauvreau, and Paul M. O'Byrne
    Factors Involved in the Pulmonary Targeting of Inhaled Glucocorticoids: The Use of Pharmacokinetic/Dynamic Simulations
    Gunther Hochhaus, Hartmut Derendorf, Helmut Möllmann, and James Talton
    Reversible Glucocorticoid Esterification
    Magnus Jendbro and Carl-Johan Johansson

    Part Five AIRWAY-LUNG SELECTIVITY OF CURRENT INHALED STEROIDS
    Airway Selectivity of Current Inhaled Corticosteroids in Properly Designed Studies
    J. Paul Seale and Paul M. O'Byrne
    Childhood Asthma and Growth
    Søren Pedersen
    Evaluation and Comparison of Inhaled Steroids
    Stanley J. Szefler and Richard J. Martin

    Part Six IN VIVO RESEARCH ON AIRWAY-LUNG SELECTIVITY
    The Role of Direct Assessment of Airway Inflammation in Evaluating Inhaled Glucocorticosteroid Efficacy and in Managing the Asthmatic Patient
    Mark D. Inman
    Use of Exhaled Nitric Oxide as Readout for Inhaled Corticosteroid Efficacy
    Sergei A. Kharitonov and Peter J. Barnes
    Markers of Systemic Actions of Corticosteroids
    Louis-Philippe Boulet
    Patient Adherence to Inhaled Corticosteroid Therapy
    Cynthia S. Rand and Kathleen Weeks Schiller

    Part Seven FUTURE CHALLENGES
    Drug Development
    Prospects for Developing Inhaled Steroids with Extrahepatic Metabolism: Soft Steroids
    Arne Thalén, Paul H. Andersson, Per T. Andersson, Bengt Axelsson, Staffan Edsbäcker, and Ralph Brattsand
    Design and Development of a Soft Corticosteroid, Loteprednol Etabonate
    Nicholas Bodor and Peter Buchwald
    Development of Inhaled Steroids Based Upon Prodrugs with Prolonged Intraluminal Retention Time
    Bengt Axelsson, Per Bäckman, Per Strandberg, and Ralph Brattsand
    Transcription Factors AP-1 and NF-kB as Targets for Development of Anti-inflammatory Drugs
    Michael Karin
    Medical Documentation Remodeling and the Effects of Steroids in Asthma
    Peter K. Jeffery
    Inhaled Corticosteroids and the Natural History of Asthma
    Fernando D. Martinez
    Combination Therapies Using Inhaled Corticosteroids
    Romain A. Pauwels and Olof Selroos

    Author Index
    Subject Index
    This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development.
    Makes connections among the underlying pharmacology, impact of new simulation models, newly recognized molecular targets, and therapeutic outcomes of short- and long-term steroid inhalation therapy!
    Containing more than 1600 works cited, drawings, tables, equations, and micrographs, Inhaled Steroids in Asthma

  • describes the developmental history of inhaled steroids and provides general models for lung selectivity
  • considers the best way to select inhaled steroids
  • clarifies local metabolism, airway and lung uptake and retention, and other determinants of once-daily usage
  • addresses variations in lung deposition and total bioavailability among available steroids and formulations
  • surveys the dynamics of receptor gene-mediated processes
  • analyzes the role of chemokines in airway allergic inflammatory diseases
  • discusses the effects of inhaled steroids in vivo on cell progenitors in asthma and rhinitis
  • details measuring airway inflammation as a guide for treatment decisions
  • outlines the clinical relevancy of exhaled nitric oxide in asthma
  • covers optimal trial design for judging antiasthmatic potency and efficacy
  • evaluates the safety of inhaled steroids
    Written by more than 40 of the world's leading authorities and investigators, Inhaled Steroids in Asthma is an authoritative reference for pulmonologists and pulmonary disease specialists; physiologists; allergists; immunologists; molecular, cell, and lung biologists; pediatricians; pharmaceutical scientists and pharmacologists; and medical school and upper-level undergraduate, graduate, and medical school students in these disciplines.
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