Injectable Drug Development : Techniques to Reduce Pain and Irritation book cover
1st Edition

Injectable Drug Development
Techniques to Reduce Pain and Irritation

ISBN 9781574910957
Published May 31, 1999 by CRC Press
472 Pages

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Book Description

Filled with strategies to minimize the adverse effects of injectable drugs, this book provides the scientific background and techniques required to evaluate parenteral formulations with respect to their potential to cause pain, irritation, and muscle damage. Using a unique, interdisciplinary approach, the book's editors and contributors represent the areas of pharmaceutics, physiology, anatomy, toxicology, and product formulation. The chapters cover topics such as muscle damage with injectables, in vitro and in vivo cystolic enzyme release, histological and morphological methods, assessing pain, cosolvents in injectables, biodegradable microparticles, and more.

Table of Contents

o Challenges, M. Akers
o Pain, Irritation & Damage, W. Klement
o Muscle Damage with Injectables, A. McArdle & M. Jackson
o In Vitro Evaluation of Intravascular Hemolysis, J. Krzyzaniak &
S. Yalkowsky
o Lesion & Edema Models, S. Sutton
o Rat Paw-Lick Model, P. Gupta
o Radiopharmaceuticals for Noninvasive Evaluation, A. Feltus, M. Jay &
R. Beihn
o In Vitro & In Vivo Cytosolic Enzyme Release, G. Brazeau
o Histological & Morphological Methods, B. Carlson & R. Palmer
o Assessing Pain, J. Marcek
o Cosolvents in Injectables, S. Way & G. Brazeau
o Prodrugs, L. Prokai & K. Prokai-Tatrai
o Complexation-Cyclodextrins, M. Brewster & T. Loftsson
o Liposomal Formulations, F. Kadir, C. Oussoren & D. Crommelin
o Biodegradable Microparticles, E. Fattal, F. Quaglia, P. Gupta &
G. Brazeau
o Emulsions, P. Gupta & J. Cannon
o Minimizing Injection Pain & Damage, L. Gatlin & C. Gatlin

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