Insight on Genotoxicity  book cover
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1st Edition

Insight on Genotoxicity




ISBN 9780367473372
Published October 15, 2020 by CRC Press
170 Pages 6 Color Illustrations

 
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Book Description

Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint.

Salient Features

  • Presents methods, standard protocols, and guidelines for genotoxicity testing
  • Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development
  • Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects
  • Discusses advancement in the high-throughput approaches for genotoxicity testing
  • Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development

Table of Contents

Introduction to Genotoxicity. Genotoxicity and DNA Repair. Consequence of DNA Damage. Mechanism of Genotoxicity. Impact of ICH Guidelines on Genotoxicity Testing: Dogmatic Obligation for Innovation Drug Discovery and Development. Genotoxicity Prediction. Computational prediction. Computational prophecy of Genotoxicity with models. Bioindicator of Genotoxicity: The Allium cepa Test. Genotoxicity appraisal of Nano sized material and particles. Genotoxicity Evaluation in Phytopharmaceuticals: Perspective Review. Deterrence of Genotoxicity: Brief Perspective. Genotoxic and non-genotoxic chemicals for review of the performance improved genotoxicity. Genotoxic impurities in Pharmaceuticals. Genotoxicity and carcinogenicity predictive software systems. Poultry manure Induced DNA Damage. Expert opinion on the basis of the content and easy understandable rundown for the reader.

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Author(s)

Biography

Dr. Shiv Shankar Shukla obtained his  Ph.D from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University. Presently he is Professor at Columbia Institute of Pharmacy. He has more than 65 publications to his credit in reputed journals. He has authored two books titled "Inflammation: Natural Resources and Its Applications" and "Finger Printing Analysis and Quality Control Methods of Herbal Medicines". He has written three book chapters published in reputed Publishing House.

Dr. Ravindra Pandey gained his Ph.D from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University. Presently he is Professor at Columbia Institute of Pharmacy. He has more than 65 publications to his credit in reputed journals. He has authored two books titled "Inflammation: Natural Resources and Its Applications" and "Finger Printing Analysis and Quality Control Methods of Herbal Medicines". He has written three book chapters in reputed Publishing House.

Dr. Bina Gidwani obtained her Ph. D from University Institute of Pharmacy, Pt. Ravishankar Shukla University. Presently, she is serving as Associate Professor at Columbia Institute of Pharmacy. She has more than 55 publications to her credit. She has authored one book and two book chapters in reputed Publishing House.

Mr. Gunjan Kalyani is Post Graduate from Chhattisgarh Swami Vivekanada Technical University (CSVTU), Bhilai, Chhattisgarh. Presently, he is Assistant Professor at Columbia Institute of Pharmacy. He has 26 publications to his credit in various journals of International and National repute.