Interferon Therapy of Multiple Sclerosis: 1st Edition (Hardback) book cover

Interferon Therapy of Multiple Sclerosis

1st Edition

Edited by Anthony Reder

CRC Press

568 pages

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Hardback: 9780824797645
pub: 1997-01-28
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This reference presents cutting-edge basic and clinical research on all forms of interferon (IFN) involvement in the management of multiple sclerosis (MS)-detailing topics from IFN-receptor molecular interactions to synergy and interference with other agents such as cytotoxic drugs and chemotherapy. Features detailed research findings on IFN ß -1a (Avonex) and IFN -1b (Betaseron).



…an excellent reference for anyone interested in the basic mechanisms of action of the interferons and the clinical chapters provide a clear account of their role in the current management of patients with multiple sclerosis."-The Canadian Journal of Neurological Sciences, 1998

Table of Contents

The Molecular Biology of Interferon-ß from Receptor Binding to Transmembrane Signaling, Lawrence M. Pfeffer and Stefan N. Constantinescu

The Molecular Biology of Type I Interferons (Interferon- /ß) (Gene Activation, Promoters, Proteins Induced), Thomas Decker

Pharmacokinetics of Interferon-ß and the Biological Markers It Induces, Patricia L. Witt

Interferons and the Central Nervous System Glia, Timothy Vartanian

Effects of Interferon on the Central Nervous System, Nachum Dafny, Bertha Prieto-Gomez, and Cruz Reyes-Vazquez

Neuropsychological Effects of Interferon Therapy, Neil H. Pliskin, Anthony T. Reder, and Diane S. Goldstein

The Effects of Interferon-ß on Cytokines and Immune Responses, Peter Rieckmann

The Pathogenetic Role of Interferon- in Multiple Sclerosis, Gianvito Martino and Luigi M. E. Grimaldi

The Effects of Interferons and Other Cytokines on Experimental Autoimmune Encephalomyelitis, Hubertine Heremans and Alfons Billiau

Effects of Oral Administration of Type I Interferons on Experimental Autoimmune Encephalomyelitis, Staley A. Brod

Interferon- in the Treatment of Multiple Sclerosis, Lorne F. Kastrukoff and Joel J.-F. Oger

Recombinant Interferon- in the Treatment of Multiple Sclerosis: Effects on Exacerbation Rate, Magnetic Resonance Imaging of Lesion Activity, and Cytokines, Luca Durelli

Inteferon ß-1a Treatment of Multiple Sclerosis, Robert M. Herndon

Inteferon ß-1b (Betaseron) Treatment of Multiple Sclerosis, Robert L. Knobler

Effects of Inteferon ß-1b on Multiple Sclerosis Lesions Evaluated by Magnetic Resonance Imaging and Other Magnetic Resonance Techniques, Robert A. Koopmans, David K. B. Li, Guo Jun Zhao, Elana Brief, Alex MacKay, Irene Vavasour, Ken Whittall, and Donald W. Paty

Adverse Effects of Interferons, Richard Cirelli, Kathleen B. Herne, Monica L. McCrary, and Stephen K. Tyring

Interferon-t: A Potential Treatment for Inflammatory Central Nervous System Disease, Jeanne M. Soos, Joel Schiffenbauer, Howard M. Johnson, and Carol H. Pontzer

Clinical Trials of Multiple Sclerosis, Jeremy C. Hobart and Alan J. Thompson

The Incidence and Clinical Significance of Antibodies to Interferon-a, Kjell Öberg and Rachel M. McKenna

Quantitation and Characterization of Multiple Sclerosis Patient Antibodies to Interferon-ß, Eirik Nestaas, James G. Files, Jeffrey W. Nelson, and Erno Pungor, Jr.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Anatomy
MEDICAL / Immunology
MEDICAL / Neurology