Interleukin-10: 1st Edition (Hardback) book cover

Interleukin-10

1st Edition

By Francesco M. Marincola

CRC Press

206 pages | 31 B/W Illus.

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Hardback: 9781587062858
pub: 2006-01-26
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Description

Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor transfectant models) or systemically (transgenic models, administration of soluble cytokine) provided. In addition, recent work has suggested that polymorphisms of the promoter region of IL-10 may segregate propulsions in high and low producers. Surprisingly, high IL-10 producers may be more predisposed to acquire cancer and other diseases. Finally, human observations demonstrate that systemic administration of IL-10 to normal volunteers is associated with very little toxicity and pro-inflammatory properties mediated through activation of effector cells of the innate immune response. Thus, the role that interleukin-10 plays in vivo in physiological or pathological conditions remains controversial. Thus, there exists a compelling need to summarize in a book the state of the science of this important cytokine. With the assistance of several experts in this field, Interleukin-10 has attempted this endeavor.

Subject Categories

BISAC Subject Codes/Headings:
MED014000
MEDICAL / Clinical Medicine
MED044000
MEDICAL / Immunology
SCI008000
SCIENCE / Life Sciences / Biology / General
SCI029000
SCIENCE / Life Sciences / Genetics & Genomics