206 Pages
31 B/W Illustrations
by
CRC Press
206 Pages
by
CRC Press
Also available as eBook on:
Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor... Read more
Preface 1. Interleukin-10 1A. Structure and Function of IL-10 and the IL-10 Receptor IB. IL-10 Effects on Innate Immunity 1C. Interleukin-10 and Adaptive Immune Response 2. Experimental Models for the Analysis of IL-10 Function III. Genetic Polymorphism of IL-10 and Relevance to Immune Function 3A. Role of IL-10 in Autoimmune Pathology 3B. Interleukin-10 Gene Polymorphisms and Cancer 3C. IL-10 Gene Polymorphisms in Transplantation 3D. IL-10, Genetic Polymorphism and Its Relevance to Age-Related Diseases 4. IL-10: Role in Infectious Diseases V. Role of IL-10 in Allergy 5. Interleukin-10 in Allergic Disease VI. Role of IL-10 in Autoimmune Pathology 6. The Role of IL-10 in Autoimmune Pathology VII. Role of IL-10 in Transplantation 7. Role of Interleukin-10 in Transplantation VIII. Role of IL-10 in Inflammatory Disease 8A. Role of IL-10 in Reactive Arthritis and Ankylosing Spondylitis 8B. Interleukin-10 and Psoriasis 8C. IL-10: The Role in Crohn’s Disease 8D. IL-10 and Systemic Lupus Erythematosus 9. Role of IL-10 in Cancer
Biography
Francesco M. Marincola, Immunogenetic Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, U.S.A.
