This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.
Table of Contents
1. Cellular Immunotherapy of Cancer: Preclinical and Clinical Testing Utilizing Interleukin-2 2. Long-Term Culture of IL-2-Generated Killer Cells with Antitumor Activity 3. Function of Interleukin-2 Activated NK Cells in Leukaemia Resistance and Treatment 4. Utilizing Lymphokine-Activated Killer Cells for Bone Marrow Purging 5. Cell-Mediated Cytotoxicity Against Fresh Solid Tumor Cells 6. Regulation by Soluble Mediators 7. Down-Regulation of Human Bone Marrow Cells and Their Progenitors by IL-2 Activated Lymphocytes 8. IL-2-Induced Cytotoxic Cells From Human Thymocytes. Regulation of NK Cytotoxicity In Vivo in Patients Receiving IL-2 9. Synergism Between Cyclophosphamide and Interleukin-2 10. Human TIL and Their Characterization 11. Growth Kinetics, Function and Characterization of Tumor-Infiltrating Lymphocytes from Human Ovarian Cancers 12. Cancer Treatment Using IL-2-Activated Killer Cells and/or IL-2 in Combination with Chemotherapeutic Drugs: Animal Studies 13. Development of Adoptive Immunotherapy with In Vitro Sensitized T Lymphocytes from Mice Bearing Progressively Growing Tumors 14. Adoptive Transfer of T Cells for Therapy of Disseminated Leukemia: Antigen Specificity and Function of Tumor-Reactive T Cells 15. LAK Cells and Autologous Bone Marrow Transplantation: Toward a Cure for Leukaemia 16. Tumor Inhibitory Effects of Regional Interleukin-2 Administration and the Role of Lymphokine-Activated Killer Cells 17. Tissue Distribution and Localization of IL-2 Activated Killer Cells After Adoptive Transfer In Vivo 18. In Vivo Tissue Distribution of Interleukin-2 Activated Cells 19. Role of rIL-2 in Host Resistance Against Cryptococcal Infection 20. Role of IL-2 in Growth and Differentiation of Cytotoxic Cells 21. The Interleukin-2 Receptor Complex and Its Role in the Induction of Nonspecific Cytotoxicity 22. Regulation of Phosphorylation and Gene Expression in Cytotoxic Lymphocytes by Interleukin-2 23. Role of the Interleukin-2 Receptor in the Growth and Regulation of LAK Activity 24. Surface Structures Involved in Tumor Cell