Introduction to Bioinformatics with R : A Practical Guide for Biologists book cover
1st Edition

Introduction to Bioinformatics with R
A Practical Guide for Biologists

  • Available for pre-order. Item will ship after November 3, 2020
ISBN 9781138498952
November 3, 2020 Forthcoming by Chapman and Hall/CRC
310 Pages 75 Color Illustrations

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Book Description

In biological research, the amount of data available to researchers has increased so much over recent years, it is becoming increasingly difficult to understand the current state of the art without some experience and understanding of data analytics and bioinformatics. An Introduction to Bioinformatics with R: A Practical Guide for Biologists leads the reader through the basics of computational analysis of data encountered in modern biological research. With no previous experience with statistics or programming required, readers will develop the ability to plan suitable analyses of biological datasets, and to use the R programming environment to perform these analyses. This is achieved through a series of case studies using R to answer research questions using molecular biology datasets. Broadly applicable statistical methods are explained, including linear and rank-based correlation, distance metrics and hierarchical clustering, hypothesis testing using linear regression, proportional hazards regression for survival data, and principal component analysis. These methods are then applied as appropriate throughout the case studies, illustrating how they can be used to answer research questions.

Key Features:

·         Provides a practical course in computational data analysis suitable for students or researchers with no previous exposure to computer programming.

·         Describes in detail the theoretical basis for statistical analysis techniques used throughout the textbook, from basic principles

·         Presents walk-throughs of data analysis tasks using R and example datasets. All R commands are presented and explained in order to enable the reader to carry out these tasks themselves.

·         Uses outputs from a large range of molecular biology platforms including DNA methylation and genotyping microarrays; RNA-seq, genome sequencing, ChIP-seq and bisulphite sequencing; and high-throughput phenotypic screens.

·         Gives worked-out examples geared towards problems encountered in cancer research, which can also be applied across many areas of molecular biology and medical research.

This book has been developed over years of training biological scientists and clinicians to analyse the large datasets available in their cancer research projects. It is appropriate for use as a textbook or as a practical book for biological scientists looking to gain bioinformatics skills.

Table of Contents


Introduction to R

An Introduction to LINUX for Biological Research

Statistical Methods for Data Analysis

Analyzing Generic Tabular Numeric Datasets in R

Functional Enrichment Analysis

Integrating Multiple Datasets in R

Analyzing Microarray Data in R

Analyzing DNA Methylation Microarray Data in R

DNA Analysis With Microarrays

Working with Sequencing Data

Genomic Sequence Profiling



Bisulphite Sequencing

Final Notes

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Ed Curry is a research fellow at Imperial College London, where he teaches topics in bioinformatics to biomedical scientists and clinicians at both undergraduate and postgraduate level. He established a successful continuing professional development course, ‘Introduction to Bioinformatics for Cancer Research’ which ran from 2012-2015. From 2015 his short course has run as part of the bioinformatics teaching for the ‘Cancer Informatics’ masters programme, for which he is senior tutor.