448 pages | 80 B/W Illus.
Advances in pharmacogenomics and proteomics, along with the introduction of recombinant DNA technology, have expanded the applications of pharmacology to encompass a range of disciplines. Biomedical researchers, protein specialists, and molecular biologists are all involved in the development and delivery of novel drugs. Therefore, students in a variety of life sciences now require grounding in pharmacology.
Adding much new material, Introduction to Pharmacology, Third Edition familiarizes students with the curative action of specific drugs, along with current research and the multifaceted role of pharmacology in society.
New to the third edition—
· Chapters on smooth muscle pharmacology covering gastrointestinal and pulmonary pharmacology
· Pharmacology advances at the molecular level
· The historical background of the Watson Crick model of DNA
· Cutting edge topics such as RNA interference and dopamine signaling
The text begins with a discussion on the absorption, distribution, metabolism, and elimination of drugs. Much emphasis is placed on pharmacokinetic aspects: how drugs produce an effect and the quantification of these effects for comparative purposes. Also the text describes substance abuse pharmacology and the evolution of drug laws. Several chapters deal with the development of drugs and challenges faced in drug discovery.
Identifying both the therapeutic and toxicological aspects of drug use, Introduction to Pharmacology employs contemporary examples to help students become familiar with drug development and treatment, as well as possible adverse affects, and the impact of drug research and use on society today and into the future.
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PART I- FUNDAMENTALS OF PHARMACOKINETICS
Absorption and Distribution
Metabolism and Elimination
PART II- FUNDAMENTALS OF PHARMACODYNAMICS AND TOXICODYNAMICS
Treating Drug Toxicity
PART III- DRUGS THAT REPLACE, CURE, OR TREAT SYMPTOMS
Chemotherapeutic Agents: Antibiotics and Anticancer Drugs
Drug Treatment of Symptoms: Neuropharmacology and Substance Abuse
PART IV- DRUG DEVELOPMENT
Drug Discovery by the Pharmaceutical Industry
Pharmaceutical Development of Drugs and the FDA
Animals in Research
PART V- APPENDICES, GLOSSARY, AND CALCULTIONS
Appendix I: The History of Drug Abuse Laws in the United States
Appendix II: Molecular Structure of Nucleic Acids
Appendix III: Glossary
Appendix IV: Top 10 Drugs in History
Appendix V: Answers to Self-Assessment Questions