4th Edition

Introduction to Toxicology

By John Timbrell, Frank A. Barile Copyright 2023
    316 Pages 1 Color & 69 B/W Illustrations
    by CRC Press

    316 Pages 1 Color & 69 B/W Illustrations
    by CRC Press

    316 Pages 1 Color & 69 B/W Illustrations
    by CRC Press

    As with the previous editions, Introduction to Toxicology, Fourth Edition, continues to chart the evolution of the field of toxicology, from the use of natural toxins by ancient tribes through the developments established by Paracelsus, and progresses through to the current topics in the public interest. For centuries, the study of toxicology has fascinated students. The book begins with basic toxicological principles, including an historical summary, dose-response relationships (NEW chapter), exposure-response relationships (NEW chapter), disposition, and metabolism of xenobiotic toxic substances. Other important new chapters include target organ toxicity, toxicity of carcinogenic agents and new and updated concepts in toxicity testing, and antidotes and treatment of poisonings. In all, nine new or expanded chapters from the third edition are advanced.

    Current concerns about the effects of therapeutic drugs, carcinogens, industrial toxins, pesticides, and herbicides on human health, animal welfare, and the stability and maintenance of the ecosystem continue to highlight toxicology as an important and growing scientific discipline.

    Key features:

    • Comprehensive coverage of the field of toxicology which illustrates its importance to and impact on society
    • Uses pertinent examples, tables, and diagrams to aid understanding with learning objectives, summaries, questions, and answers for each chapter
    • Clearly and concisely written and presented concepts for easy comprehension by toxicology, biomedical, and health science students
    • Examines the complex interactions associated with toxicological events
    • Covers the effect of toxins on biological and physiological systems

    This book successfully condenses the diffuse literature in the field into an accessible and readable text, made easier with the insertion of many tables and figures. It introduces fundamental concepts and builds upon these using topical and relevant historical examples. Its improved format includes learning objectives and summaries of each chapter, as well as questions and answers suitable for self-assessment.

    This latest edition is an invaluable resource for undergraduate and graduate toxicology students, as well as an introductory text for other health care students and professionals. The book also functions as a comprehensive introductory reference text for environmental scientists, medical biologists and chemists, chemical engineers, and regulatory agencies, with interests in toxicologically related areas.

    1. Introduction. 2. Dose-Response Relationship. 3. Exposure-Response Relationship. 4. Disposition of Toxic Compounds. 5. Metabolism of Xenobiotic Compounds. 6. Target Organ Toxicity. 7. Carcinogenic and Mutagenic Compounds. 8. Drugs as Toxic Substances. 9. Industry Toxicology. 10. Food Additives and Contaminants. 11. Pesticides and Herbicides. 12. Environmental Pollutants. 13. Natural Products. 14. Commercial and Domestic Products. 15. Fundamentals of Toxicity Testing. 16. Risk Assessment. 17. Antidotes and Treatment of Poisoning. Answers to Chapter Questions. Glossary.


    John Timbrell is Emeritus Professor of Biochemical Toxicology in the Pharmacy Department at King's College London and was a member of the Commitee on Toxicigy, U.K.Govenment. He was the founding Editor of the journal Biomarkers (Taylor and Francis Ltd). Publishers. He has been involved with the teaching and development of toxicology courses at both undergraduate and postgraduate level for 30 years.

    Frank A. Barile is retired Professor of Toxicology in the Pharmaceutical sciences Department, St. John’s University College of Pharmacy and Health Sciences, New York. He is past President of the In Vitro and Alternative Methods (IVAM) Specialty Section of the U.S. Society of Toxicology and a former member of the Scientific Advisory Committee for Alternative Toxicological Methods (SACATM), NIEHS, U.S. National Institutes of Health. He is former Chief Editor of Toxicology in Vitro.