Beta cell replacement through transplantation remains the only treatment option for Type 1 diabetes enabling restoration of near-physiological glucose levels without significant hypoglycemia. Outlining the most recent advances and research breakthroughs, this practical guide and reference work explores the impact of islet cell transplantation and brings together leading multidisciplinary proponents critical to future success in the field. Edited by a surgeon and an endocrinologist at the forefront of the technology, this volume considers challenges associated with this procedure including lack of sufficient donor organs and the side effects of immunosuppressive therapy, as well as the potential benefits for current and future patients.
Islet Transplantation and Beta Cell Replacement Therapy, after a brief historical overview, examines:
"This is an excellent collection of chapters by leading experts and will likely become the standard reference for practitioners of islet transplantation. The revolutionary change in success rates and basic development since the Edmonton protocol and international enthusiasm for program development in this area make this a timely publication and a necessary update to Dr. Ricordi's 1992 book on the subject … Nonetheless, this book is an instant and welcome standard for programs, clinicians, and researchers striving to maximize and improve outcomes for patients undergoing islet transplantation." —Marc Rider Garfinkel, MD (University of Chicago Pritzker School of Medicine), Doody’s Reviews
A Historical Perspective on Experimental and Clinical Islet Transplantation. Hypoglycemia in Type 1 Diabetes: The Need for a New Approach. Patient Selection and Assessment: An Endocrinologist's Perspective. The Surgical Aspects of Pancreas Procurement for Pancreatic Islet Transplantation. Pancreas Preservation for Islet Isolation. Aspects and Challenges of Islet Isolation. Percutaneous Portal Vein Access: Radiological Aspects. Care of the Islet Transplant Recipient - Immunosuppressive Management and Complications. Islet Graft Monitoring and Imaging. Metabolic Measures of Islet Function and Mass After Islet Transplantation. Challenges in Setting Up a New Islet Transplant Program. Key Factors to Consider in Setting Up Clinical Trials in Islet Cell Transplantation: A Nursing Coordinator's Perspective. Clinical Outcomes and Future Directions in Islet Transplantation. Culture and Transportation of Human Islets Between Centers. Development and Application of Contemporary Immunosuppresion in Human Islet Transplantation. Pig Islet Xenotransplantation-Update and Context. Approaches to ß-cell Regeneration and Neogenesis. Stem Cell Approaches for ß-cell Replacement. Diabetes Gene Therapy