1st Edition

JAK-STAT Signaling in Diseases

Edited By Ritobrata Goswami Copyright 2020
290 Pages 21 Color & 13 B/W Illustrations
by CRC Press

290 Pages 21 Color & 13 B/W Illustrations
by CRC Press

JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth... Read more

1. Regulation of Cytokine Signaling by the JAK-STAT Pathway
Nicolette Nadene Houreld

2. The Structure-Function Bonhomie of JAK-STAT Molecules
Ritobrata Goswami

3. MicroRNA-Mediated Regulation of JAK-STAT Signaling in Non-Cancerous Human Diseases
Chandra S. Boosani, Wanlin Jiang, Taylor Burke and Devendra K. Agrawal

4. JAK-STAT Signaling in Asthma and Allergic Airway Inflammation
Amina Abdul Qayum, Tristan Hayes and Mark H. Kaplan

5. Role of JAK-STAT Signaling in Atopic Dermatitis
Radomir M. Slominski and Matthew J. Turner

6. JAK/STAT Signaling Pathway and Gliosis in Neuroinflammatory Diseases
Han-Chung Lee, Kai-Leng Tan, Pike-See Cheah and King-Hwa Ling

7. JAK-STAT Signaling in Cardiovascular Disease
George W. Booz, Raffaele Altara and Sean P. Didion

8. Diabetes and Obesity: Abnormal JAK-STAT Signaling
Marcia J. Abbott

9. JAK-STAT Signaling in Liver Fibrosis
Marwa K. Ibrahim and Noha G. Bader El Din

10. Renal Disorders: Involvement of JAK-STAT Pathway
Yuji Nozaki

11. JAK-STAT Signaling in Hematologic Malignancies
Thomas Pincez and Thai Hoa Tran

12. Aberrant JAK-STAT Signaling in Hematopoietic Malignancies
Parvis Sadjadian

13. Immunodeficiency: Consequences of Mutations in JAK-STAT Signaling
Daniel Silberger and Duy Pham

14. Targeting JAK-STAT Pathway for Various Inflammatory Diseases and Viral Infections
Christina Gavegnano and Raymond F. Schinazi

Biography

Ritobrata Goswami, PhD is presently working as an Assistant Professor in the School of Bioscience, IIT Kharagpur since 2016. Prior to his present affiliation, Dr Goswami was associated with the Division of Biological and Life Sciences, Ahmedabad University (2014-16). He received his bachelor (2005) and masters degree (2007) in Biotechnology from West Bengal University of Technology and Birla Institute of Technology & Science, Pilani; respectively. Dr Goswami obtained his PhD at Indiana University, Indianpolis, USA (2012) followed by post-doctoral training at the Icahn School of Medicine at Mount Sinai, New York, USA (2012-14). He is a life member of the Indian Immunology Society. Dr Goswami has extramural projects funded by the Government of India. Dr Goswami’s research interests include the role of nutrients and hormones in the development and function of T helper cells to regulate inflammatory disorders. He is keen on identifying a regulating network of transcription factors involved in autoimmune and inflammatory disorders so that better therapeutics can be developed.