1st Edition

Juvenile Hormones and Juvenoids Modeling Biological Effects and Environmental Fate

Edited By James Devillers Copyright 2013
    401 Pages 14 Color & 211 B/W Illustrations
    by CRC Press

    401 Pages 14 Color & 211 B/W Illustrations
    by CRC Press

    Juvenile hormones (JHs) are a group of structurally related sesquiterpenes secreted by the insect corpora allata. They affect most insect life-cycle stages and physiological functions, including embryogenesis, larval and adult development, metamorphosis, reproduction, metabolism, diapause, polyethism, and migration. Juvenoids such as methoprene, hydroprene, kinoprene, pyriproxyfen, and fenoxycarb are man-made chemicals that mimic the structure and/or activity of JHs, selectively targeting and disrupting the endocrine system of insects. They are particularly suited as larvicides for the control of pest and disease vectoring insects such as mosquitoes.

    Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate
    discusses the various modeling approaches that can be used to study the mechanism of action of JHs in insects and to estimate the adverse effects and the environmental fate of the juvenoids that mimic their activity. This book is the third of the QSAR in Environmental and Health Sciences series, but the first dedicated to the use of QSAR and other in silico techniques to provide these insights into JHs and their analogs.

    With contributions by an international team of scientists, the book begins with a historical survey of JHs and juvenoids. It then discusses biosynthesis of sesquiterpenoids followed by chapters covering JH activity such as morph-specific JH titers in crickets, and JH analog activity including soldier-specific organ development in termites and the role of methoprene in gene transcription. The book examines modeling approaches applied to resistance to JH analogs, to population dynamics of nontarget species in the presence of juvenoids, and to SAR and QSAR of JH mimics. The book concludes with a discussion on the use of multicriteria analysis for selecting insecticides for vector control.

    Juvenile Hormones and Juvenoids: A Historical Survey
    James Devillers

    Future Perspectives for Research on the Biosynthesis of Juvenile Hormones and Related Sesquiterpenoids in Arthropod Endocrinology and Ecotoxicology
    Jerome H.L. Hui, William G. Bendena, and Stephen S. Tobe

    Morph-Specific JH Titer Regulation in Wing-Polymorphic Gryllus Crickets: Proximate Mechanisms Underlying Adaptive Genetic Modification of JH Regulation
    Anthony J. Zera

    Soldier-Specific Organ Developments Induced by a Juvenile Hormone Analog in a Nasute Termite
    Kouhei Toga and Kiyoto Maekawa

    Roles of Juvenile Hormone Analog Methoprene in Gene Transcription
    Xiao-Fan Zhao

    Modeling Resistance to Juvenile Hormone Analogs: Linking Evolution, Ecology, and Management
    David W. Crowder, Peter C. Ellsworth, Steven E. Naranjo, Bruce E. Tabashnik, and Yves Carrière

    Population Dynamics Models for Assessing the Endocrine Disruption Potential of Juvenile Hormone Analogues on Nontarget Species
    James Devillers and Hugo Devillers

    SAR and QSAR Modeling of Juvenile Hormone Mimics
    James Devillers

    Using CoMFA and CoMSIA as Tools in a 3D QSAR Analysis of Juvenile Hormone Agonist Action in Drosophila
    Robert Farkaš and Maja Polakovičová
    Predicting Highly Potent Juvenile Hormone Esterase Inhibitors from 2D QSAR Modeling
    James Devillers, Annick Doucet-Panaye, and Jean-Pierre Doucet

    Receptor-Guided Structure–Activity Modeling of Inhibitors of Juvenile Hormone Epoxide Hydrolases
    Julio Caballero

    Structural Studies of Juvenile Hormone-Binding Proteins
    Agnieszka J. Pietrzyk, Mariusz Jaskolski, and Grzegorz Bujacz

    In Silico
    Stereoelectronic Profile and Pharmacophore Similarity Analysis of Juvenile Hormone, Juvenile Hormone Mimics (IGRs), and Insect Repellents May Aid Discovery and Design of Novel Arthropod Repellents
    Apurba K. Bhattacharjee

    Use of Multicriteria Analysis for Selecting Candidate Insecticides for Vector Control
    James Devillers, Laurent Lagadic, Ohri Yamada, Frédéric Darriet, Robert Delorme, Xavier Deparis, Jean-Philippe Jaeg, Christophe Lagneau, Bruno Lapied, Françoise Quiniou, and André Yébakima


    James Devillers has authored/edited 13 books and published more than 200 peer-reviewed papers and book chapters in QSAR and (eco)toxicology modeling. He is editor-in-chief of the journal SAR and QSAR in Environmental Research (Taylor & Francis) and editor of the series of books QSAR in Environmental and Health Sciences (CRC Press). James Devillers is also member of the editorial boards of Ecological Modelling (Elsevier), Xenobiotica (Taylor & Francis), and Current Bioactive Compounds (Bentham Science).