Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate, 1st Edition (Hardback) book cover

Juvenile Hormones and Juvenoids

Modeling Biological Effects and Environmental Fate, 1st Edition

Edited by James Devillers

CRC Press

401 pages | 14 Color Illus. | 211 B/W Illus.

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Juvenile hormones (JHs) are a group of structurally related sesquiterpenes secreted by the insect corpora allata. They affect most insect life-cycle stages and physiological functions, including embryogenesis, larval and adult development, metamorphosis, reproduction, metabolism, diapause, polyethism, and migration. Juvenoids such as methoprene, hydroprene, kinoprene, pyriproxyfen, and fenoxycarb are man-made chemicals that mimic the structure and/or activity of JHs, selectively targeting and disrupting the endocrine system of insects. They are particularly suited as larvicides for the control of pest and disease vectoring insects such as mosquitoes.

Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate discusses the various modeling approaches that can be used to study the mechanism of action of JHs in insects and to estimate the adverse effects and the environmental fate of the juvenoids that mimic their activity.This book is the third of the QSAR in Environmental and Health Sciences series, but the first dedicated to the use of QSAR and other in silico techniques to provide these insights into JHs and their analogs.

With contributions by an international team of scientists, the book begins with a historical survey of JHs and juvenoids. It then discusses biosynthesis of sesquiterpenoids followed by chapters covering JH activity such as morph-specific JH titers in crickets, and JH analog activity including soldier-specific organ development in termites and the role of methoprene in gene transcription. The book examines modeling approaches applied to resistance to JH analogs, to population dynamics of nontarget species in the presence of juvenoids, and to SAR and QSAR of JH mimics. The book concludes with a discussion on the use of multicriteria analysis for selecting insecticides for vector control.

Table of Contents

Juvenile Hormones and Juvenoids: A Historical Survey

James Devillers

Future Perspectives for Research on the Biosynthesis of Juvenile Hormones and Related Sesquiterpenoids in Arthropod Endocrinology and Ecotoxicology

Jerome H.L. Hui, William G. Bendena, and Stephen S. Tobe

Morph-Specific JH Titer Regulation in Wing-Polymorphic Gryllus Crickets: Proximate Mechanisms Underlying Adaptive Genetic Modification of JH Regulation

Anthony J. Zera

Soldier-Specific Organ Developments Induced by a Juvenile Hormone Analog in a Nasute Termite

Kouhei Toga and Kiyoto Maekawa

Roles of Juvenile Hormone Analog Methoprene in Gene Transcription

Xiao-Fan Zhao

Modeling Resistance to Juvenile Hormone Analogs: Linking Evolution, Ecology, and Management

David W. Crowder, Peter C. Ellsworth, Steven E. Naranjo, Bruce E. Tabashnik, and Yves Carrière

Population Dynamics Models for Assessing the Endocrine Disruption Potential of Juvenile Hormone Analogues on Nontarget Species

James Devillers and Hugo Devillers

SAR and QSAR Modeling of Juvenile Hormone Mimics

James Devillers

Using CoMFA and CoMSIA as Tools in a 3D QSAR Analysis of Juvenile Hormone Agonist Action in Drosophila

Robert Farkaš and Maja Polakovičová Predicting Highly Potent Juvenile Hormone Esterase Inhibitors from 2D QSAR Modeling

James Devillers, Annick Doucet-Panaye, and Jean-Pierre Doucet

Receptor-Guided Structure–Activity Modeling of Inhibitors of Juvenile Hormone Epoxide Hydrolases

Julio Caballero

Structural Studies of Juvenile Hormone-Binding Proteins

Agnieszka J. Pietrzyk, Mariusz Jaskolski, and Grzegorz Bujacz

In Silico Stereoelectronic Profile and Pharmacophore Similarity Analysis of Juvenile Hormone, Juvenile Hormone Mimics (IGRs), and Insect Repellents May Aid Discovery and Design of Novel Arthropod Repellents

Apurba K. Bhattacharjee

Use of Multicriteria Analysis for Selecting Candidate Insecticides for Vector Control

James Devillers, Laurent Lagadic, Ohri Yamada, Frédéric Darriet, Robert Delorme, Xavier Deparis, Jean-Philippe Jaeg, Christophe Lagneau, Bruno Lapied, Françoise Quiniou, and André Yébakima

About the Editor

James Devillers has authored/edited 13 books and published more than 200 peer-reviewed papers and book chapters in QSAR and (eco)toxicology modeling. He is editor-in-chief of the journal SAR and QSAR in Environmental Research (Taylor & Francis) and editor of the series of books QSAR in Environmental and Health Sciences (CRC Press). James Devillers is also member of the editorial boards of Ecological Modelling (Elsevier), Xenobiotica (Taylor & Francis), and Current Bioactive Compounds (Bentham Science).

About the Series

QSAR in Environmental and Health Sciences

The aim of the book series is to publish cutting-edge research and the latest developments in QSAR modeling applied to environmental and health issues. Its aim is also to publish routinely used QSAR methodologies to provide newcomers to the field with a basic grounding in the correct use of these computer tools. The series is of primary interest to those whose research or professional activity is directly concerned with the development and application of SAR and QSAR models in toxicology and ecotoxicology. It is also intended to provide graduate and postgraduate students with clear and accessible books covering the different aspects of QSARs.

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Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Chemistry / Physical & Theoretical
SCIENCE / Life Sciences / Zoology / Entomology
SCIENCE / Environmental Science