5th Edition

Karch's Pathology of Drug Abuse




ISBN 9781439861462
Published November 11, 2015 by CRC Press
912 Pages 313 Color Illustrations

USD $185.00

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Book Description

Written in the same accessible manner as previous editions, the fifth edition of Karch’s Pathology of Drug Abuse is an essential guide to the pathology, toxicology, and pharmacology of commonly abused drugs. The book focuses on the investigation of drug-related deaths, practical approaches to the detection of drug abuse, and discussions of medical complications associated with each of the abused drugs.

The Fifth Edition Now Features:

  • Completely revised with hundreds of pages of wholly new coverage
  • Extensive discussion of new synthetic cannabinoids and cathinone derivatives
  • Expanded coverage of the functional and molecular pharmacology of cocaine and myocardial remodeling
  • Expanded discussion of deaths related to prescription medications
  • Detailed suggestions on the interpretation of postmortem drug measurements
  • Many new high resolution full-color photomicrographs
  • Additional, helpful new appendices on standard reference values

Separate chapters are devoted to cocaine, naturally occurring stimulants, synthetic stimulants, hallucinogens, narcotics, anabolic steroids, disassociative anesthetics, solvent abuse, and marijuana. The book also offers detailed information on the origins, history, and production techniques used to make many of these drugs. Updated, revised, and newly illustrated, Karch’s Pathology of Drug Abuse, Fifth Edition is a must-have reference for research and practice related to drug abuse.

Steven B. Karch also discusses the book in a video on the CRC Press YouTube channel.

Table of Contents

Cocaine
Prevalence of Abuse
Epidemiology
History
Current Affairs
Metabolism of Cocaine and Its Metabolites
Fetal Metabolism
Routes of Ingestion
Problems of Cocaine Test Interpretation
Cocaine Adulterants
Cocaine Tissue Disposition and Postmortem Redistribution
Electrophysiology of Sudden Death in Cocaine Abusers
External Markers of Cocaine Abuse
Skin Toxicity
Cardiovascular System: General Overview
Excited Delirium Syndrome
Cocaine-Associated Pulmonary Disease
Neurologic Disorders: Introduction
Renal Disease
Hematologic Abnormalities
Hormonal Alterations
Immune System Abnormalities
Gastrointestinal Disorders
Analytic and Forensic Toxicology
Pregnancy Interactions
When Is Cocaine the Cause of Death?
References

Natural Stimulants
Absinthe
Caffeine
Ephedrine
References

Synthetic Stimulants
Amphetamines
Methylphenidate
Captagon
Other Stimulants
New Synthetic Stimulants
Cathinone
Structural Analogs of Cathinone
References

Hallucinogens
Introduction
Production and Consumption
Tryptamine Derivatives
Hallucinogenic Amphetamines
Phenylalkylamines
Psilocybin
α-Ethyltryptamine
Lysergic Acid Diethylamide
References

Opiates and Opioids
Worldwide Opium Consumption
Epidemiology
Classifying Narcotic and Nonnarcotic Agents
History
Cultivation and Manufacture
Heroin Diluents and Adulterants
Prices and Purity
Morphine and Heroin
Tissue Disposition
Interpretation of Opiate Blood and Tissue Concentrations
Synthetic Opioids: General Considerations
Medical Consequences of Opiate Abuse
Bioanalytic Considerations
References

Dissociative Anesthetics
Introduction to Dissociative Anesthetics
Phencyclidine
Methoxetamine
Ketamine
Gamma-Hydroxybutyrate and Related Substances
Pregabalin
Salvia divinorum
Dextromethorphan
Propofol
References

Anabolic–Androgenic Steroids
Prevalence and Epidemiology
History
Pharmacology
Testosterone and Aging
Patterns of Steroid Abuse
Testosterone and Nandrolone
Other Abused Steroids
Legitimate Indications for Dispensing Anabolic–Androgenic Steroids
Steroid-Related Disorders
Selective Androgen Receptor Modulators
Detecting Steroid Abuse in the Living
Postmortem Analysis
References

Solvents
Incidence and Epidemiology
General Considerations: Availability and Types of Products
Disposition: Absorption and Tissue Concentrations
Pharmacology and Toxicology
Clinical Syndromes
Toxicology
References

Marijuana
Botany
Epidemiology
Pharmacology
Metabolism and Disposition
Detection Times
Cardiovascular Effects
Pulmonary Complications
Synthetic Cannabinoids
Selective THC Agents
Postmortem Considerations
Toxicology
References

Appendix A: Conversion Formulas

Appendix B: Blood Ethanol Concentrations

Appendix C: Volume of Distribution Calculations

Appendix D: Methods for Determining Normal Heart Weight

Appendix E: Normal Organ Weights

Appendix F: Collecting and Documenting Pills from the Scene of a Death

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Author(s)

Biography

Steven B. Karch, MD, received his medical degree from Tulane University in New Orleans and did postgraduate training in neuropathology at The Royal London Hospital and in cardiac pathology at Stanford University. He is a fellow of the Faculty of Forensic and Legal Medicine of the Royal College of Physicians of London and a fellow of the Forensic Science Society. He has also been active in The Royal Society of Medicine since his election as a Wellcome fellow in 1972. He is the author of nearly 100 papers and book chapters, most relating to the effects of drug abuse on the heart. He has also published 12 books and is an associate editor for the Journal of Cardiovascular Toxicology.

Olaf H. Drummer, PhD, is deputy director of academic programs at the Victorian Institute of Forensic Medicine as well as professor and head of the Department of Forensic Medicine at Monash University. He earned his PhD in pharmacology from Melbourne University. He has been involved in the analysis and interpretation of the biological effects of drugs and poisons for nearly 40 years, and lectures widely on these subjects. He is a member of numerous professional societies and has published more than 200 peer-reviewed scientific papers in journals as well as many other reports, book chapters, and encyclopedia articles. He is the main author of The Forensic Pharmacology of Drugs of Abuse and the editor for drugs and toxicology submissions for the journal Forensic Science International.

Reviews

"It is easy today for physicians to become technicians rather than professionals. A technician knows how to respond to a problem. The professional has the depth of knowledge that brings real understanding to a problem. This book presents a comprehensive view of each subject that it discusses. Dr. Karch's book is a book for professionals."
Journal of Forensic Science