1st Edition

Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging

Edited By Carlos F.G.C. Geraldes Copyright 2024
426 Pages 82 Color & 66 B/W Illustrations
by CRC Press

426 Pages 82 Color & 66 B/W Illustrations
by CRC Press

426 Pages 82 Color & 66 B/W Illustrations
by CRC Press

Since the development of the first clinical MRI contrast agent, Gd(DTPA) (or Magnevist®) in the early 1980s, another three linear and three macrocyclic (eg. Gd(DOTA) (Dotarem®) have been introduced in the clinic and inspired a huge number of researchers worldwide to perform preclinical research to obtain contrast agents for many kinds of clinical applications, which are described in this book.... Read more

Chapter 1 Synthesis and Characterization of Ligands and Their Gd(III) Complexes

Raphaël Tripier, Maryline Beyler

 

Chapter 2 PARASHIFT Systems: Including 19F Effects

Peter Harvey

 

Chapter 3 Targeted MRI Contrast Agents

Alexander G. Sertage, Md. Sydul Islam, and Matthew J. Allen

 

Chapter 4 Responsive MRI Contrast Agents

Luke A. Marchetti, Manon Isaac, Célia S. Bonnet

 

Chapter 5 Mn-Based Small Complexes as MRI Contrast Agents

Zoltán Garda, Sara Lacerda and Éva Tóth

 

Chapter 6 Other First-Row Transition Metal-Based Complexes as MRI Contrast Agents

Janet R. Morrow and Jaclyn J. Raymond

 

Chapter 7 Lanthanide-based paramagnetic chemical exchange saturation transfer (paraCEST) agents for MRI

A. Dean Sherry & Mark Woods

 

Chapter 8 LipoCEST and Similar Systems

Silvio Aime and Enzo Terreno

 

Chapter 9 Superparamagnetic Iron Oxide and Ferrite Nanoparticles for MRI

Thomas Vangijzegem, Levy Van Leuven, Dimitri Stanicki, Robert N. Muller, Sophie Laurent

 

Chapter 10 Ln-based particles as MRI contrast agents

Joop A. Peters and Kristina Djanashvili

 

Chapter 11 Manganese and Iron Based Nanoparticles as MRI Contrast Agents

Fabio Carniato, Lorenzo Tei, and Carlos F,G. C. Geraldes

 

Chapter 12 Advances in PET/MRI and Probe Development for Biomedical Precision Imaging Applications

Jan Kretschmer, Juan Pellico, Angelina Prytula-Kurkunova, Rafael Torres Martin De Rosales, Andre Ferreira Martins

Biography

Carlos F. G. C. Geraldes received his “Licenciatura” (MS equivalent) in Chemistry from the University of Coimbra in 1972, and his Doctor of Philosophy (D.Phil) degree in Inorganic Chemistry from the University of Oxford in 1976 with Prof. Robert J. P. Williams. In his graduate work, he studied the solution conformation of a series of mono and dinucleotides using the so-called Lanthanide Probe Method, measuring the proton NMR induced shifts and nuclear relaxation rates of their complexes of whole paramagnetic Ln(III) series combined with coupling constants and NOE data.