Chapter 1: Exploring Introductory Principles
Chapter 2: A Refresher on Fluid Flow and Mixing
Chapter 3: Experimental Determination and Application of Oxygen Mass-Transfer Rate, Mass-Transfer Coefficient, and Oxygen-Uptake Rate
Chapter 4: Physiochemical Factors Affecting Oxygen Transfer and the Volumetric Mass-Transfer Coefficient in Stirred Tanks
Chapter 5: Theoretical and Empirical Correlations for Predicting the Mass-Transfer Coefficient in Stirred-Tank Bioreactors
Chapter 6: Dissolved Carbon Dioxide and Its Impact on Cell-Culture Systems
Chapter 7: Insights into Dissolved Carbon Dioxide (dCO2) Accumulation in Cell-Culture Bioreactors
Chapter 8: Strategies To Control dCO2 Accumulation Using Aeration Flow Rate
Chapter 9: Use of Mathematical Models To Design dCO2 Stripping Strategies
Biography
Muhammad “Arshad” Chaudhry is working as Director – Cell Line and Upstream Process Development at Disc Medicine for the last one year. Prior to that, he has worked in various roles in upstream processing covering a wide range of biologics (monoclonal antibody, fusion proteins, allogeneic cell therapy, lenti- and AAV -based viral vectors). He has been in the cell culture field for almost 20 years now and has worked mostly in the upstream process development supporting both early and late-stage projects covering CMC activities, GMP manufacturing of clinical grade material, QbD based scale-down model development and process characterization studies. He holds a Ph.D. in Biochemical engineering from University of British Columbia, Vancouver Canada having worked under Dr. James Piret’s guidance on embryonic stem cell bioengineering and fed-batch process development projects.
