Chapter 1: Exploring Introductory Principles
Chapter 2: A Refresher on Fluid Flow and Mixing
Chapter 3: Experimental Determination and Application of Oxygen Mass-Transfer Rate, Mass-Transfer Coefficient, and Oxygen-Uptake Rate
Chapter 4: Physiochemical Factors Affecting Oxygen Transfer and the Volumetric Mass-Transfer Coefficient in Stirred Tanks
Chapter 5: Theoretical and Empirical Correlations for Predicting the Mass-Transfer Coefficient in Stirred-Tank Bioreactors
Chapter 6: Dissolved Carbon Dioxide and Its Impact on Cell-Culture Systems
Chapter 7: Insights into Dissolved Carbon Dioxide (dCO2) Accumulation in Cell-Culture Bioreactors
Chapter 8: Strategies To Control dCO2 Accumulation Using Aeration Flow Rate
Chapter 9: Use of Mathematical Models To Design dCO2 Stripping Strategies
Biography
Muhammad “Arshad” Chaudhry is working as Director – Cell Line and Upstream Process Development at Disc Medicine for the past one year. Prior to that, he has worked in various roles in upstream processing, covering a wide range of biologics (monoclonal antibodies, fusion proteins, allogeneic cell therapy, lenti- and AAV -based viral vectors, etc.). He has been in the cell culture field for almost 20 years now and has worked mostly in the upstream process development supporting both early and late-stage projects covering CMC activities, GMP manufacturing of clinical grade material, QbD-based scale-down model development and process characterization studies. He holds a Ph.D. in Biochemical Engineering from University of British Columbia, Vancouver Canada having worked under Dr. James Piret’s guidance on embryonic stem cell bioengineering and fed-batch process development projects.
