Linearly Polarized IR Spectroscopy
Theory and Applications for Structural Analysis
A technique that is useful in the study of pharmaceutical products and biological molecules, polarization IR spectroscopy has undergone continuous development since it first emerged almost 100 years ago. Capturing the state of the science as it exists today, Linearly Polarized IR Spectroscopy: Theory and Applications for Structural Analysis demonstrates how the technique can be properly utilized to obtain important information about the structure and spectral properties of oriented compounds.
The book starts with the theoretical basis of linear-dichroic infrared (IR-LD) spectroscopy and then moves on to examine the background of the orientation method of colloid suspensions in a nematic host. It explores the orientation procedure itself, experimental design, and mathematical tools for the interpretation of the IR spectroscopic patterns. Next, the authors describe the structural elucidation of inorganic and organic compounds and glasses. Finally, they discuss applications in pharmaceutical analysis and the chemistry of dyes. Filled with more than 140 illustrations along with a color insert, the book explains both the scope of the polarized IR spectroscopy method as well as its limitations.
A powerful source of information not only for specialists in IR spectroscopy, but also for those working in the field of structural analysis, this volume moves the field closer to developing an inherently classical method for the structural characterization of compounds.
Table of Contents
Linear-Dichroic Infrared (IR-LD) Spectroscopy: Background
Symmetry Analysis of Normal Vibrations and Dipole Moments of Transition Generated Therefrom
Elements and Operations of Symmetry
Symmetry Analysis of the Dipole Moments of Transition
Orientation of the Samples
Orientation in Liquid Crystal Solutions
Orientation as Suspension in Liquid Crystals
Photometrization and Processing of IR-LD Spectra: Differential Reducing Procedure
Effects in the Infrared Spectra of Crystals
Background of the Orientation Method of Colloid Suspensions in a Nematic Host
Validation of the Orientation Procedure
Accuracy and Repeatability
The Quantitative Ratio of Liquid Crystals and Solid Samples
Preliminary Rubbing Out of the KBr Plates
Peak Function Type for the Curve-Fitting Procedure
Number of Scans in the Measurements
Mathematical Tools for the Interpretation of the IR Spectroscopic Patterns
IR Spectra Subtraction
The Smoothing Procedure
Accuracy and Precision
Curve-Fitting Procedure (CFP)
Baseline Correction (BLC)
Reducing-Difference Procedure (RDP) for IR-LD Spectra Interpretation
Structural Elucidation of Inorganic Compounds and Glasses
R Spectroscopic Elucidation of Glasses
Structural Elucidation of Organic Compounds
Analysis of Heterocyclic Compounds
Small Biologically Active Molecules
Application in the Pharmaceutical Analysis
Analysis of Morphine Alkaloids
Application in the Chemistry of Dyes
Appendix: List of Acronyms
Bojidarka Ivanova, Ph.D. received her M.Sc. degree in physical and theoretical chemistry in 1997 from Sofia University (St. Kl. Okhridski), Bulgaria. She earned her Ph.D. in analytical chemistry from Sofia University in 2001. Since 2003, Dr. Ivanova has been an associate professor in chemistry, holding the corresponding position at the Department of Analytical Chemistry at Sofia University.
Tsonko Kolev, D.Sc. obtained his M.Sc. degree in chemistry in 1973 at Sofia University (St. Kl. Okhridski), Bulgaria, and his Ph.D. in organic chemistry in 1982 from the Institute of Organic Chemistry, Bulgarian Academy of Sciences. His current position is head of the Department of Organic Chemistry at Plovdiv University (P. Hilendarski), Bulgaria.