1st Edition
Liposome Drug Delivery Systems
148 Pages
by
CRC Press
148 Pages
by
CRC Press
Also available as eBook on:
Guide to current liposome drug delivery technology. Applications, preparation, pharmacokinetics, stability, passive and active targeting, and industrial production. Special emphasis on "stealth" liposomes (liposomes with extended circulation times).
* Preparation of Liposomes:
Materials - Lipid Selection - Selection of Method of Preparation - Characterization
* Stability of Liposomes:
Loss of Entrapped Drug - Changes in Liposome Structure - Phospholipid and Cholesterol Stability - Factors Affecting Liposome Stability - Freezing of Liposomes - Lyophilization
* Pharmacokinetics of Liposome Products:
Markers for Determination of Pharmacokinetics - Kinetics of Release of Liposomal in Tissues - Interactions of Liposomes with Cells - Route of Administration-Dependent Pharmacokinetics - Liposomes with Prolonged Circulation Times
* Pharmaceutical Applications of Liposomes:
Interactions of Liposomes with Cells - Liposomal Routes of Administration - Liposomal Applications - Liposome Toxicity
* Targeting of Liposomes:
Passive Targeting - Active Targeting - Pharmacokinetics of Site-Specific Drug Delivery - Targeting of pH-Sensitive Liposomes
* Industrial Applications of Liposomes:
Large-Scale Production - Removal of Nonencapsulated Drug - Freeze-Drying - Quality Control - Stability - Physical Stability - Chemical Stability - Sterilization
Materials - Lipid Selection - Selection of Method of Preparation - Characterization
* Stability of Liposomes:
Loss of Entrapped Drug - Changes in Liposome Structure - Phospholipid and Cholesterol Stability - Factors Affecting Liposome Stability - Freezing of Liposomes - Lyophilization
* Pharmacokinetics of Liposome Products:
Markers for Determination of Pharmacokinetics - Kinetics of Release of Liposomal in Tissues - Interactions of Liposomes with Cells - Route of Administration-Dependent Pharmacokinetics - Liposomes with Prolonged Circulation Times
* Pharmaceutical Applications of Liposomes:
Interactions of Liposomes with Cells - Liposomal Routes of Administration - Liposomal Applications - Liposome Toxicity
* Targeting of Liposomes:
Passive Targeting - Active Targeting - Pharmacokinetics of Site-Specific Drug Delivery - Targeting of pH-Sensitive Liposomes
* Industrial Applications of Liposomes:
Large-Scale Production - Removal of Nonencapsulated Drug - Freeze-Drying - Quality Control - Stability - Physical Stability - Chemical Stability - Sterilization
Biography
Guru V. Betageri, Scott Allen Jenkins, Daniel Parsons
