Liposome Drug Delivery Systems  book cover
1st Edition

Liposome Drug Delivery Systems

ISBN 9781566760300
Published March 1, 1993 by CRC Press
148 Pages

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Book Description

Guide to current liposome drug delivery technology. Applications, preparation, pharmacokinetics, stability, passive and active targeting, and industrial production. Special emphasis on "stealth" liposomes (liposomes with extended circulation times).

Table of Contents

* Preparation of Liposomes:
Materials - Lipid Selection - Selection of Method of Preparation - Characterization
* Stability of Liposomes:
Loss of Entrapped Drug - Changes in Liposome Structure - Phospholipid and Cholesterol Stability - Factors Affecting Liposome Stability - Freezing of Liposomes - Lyophilization
* Pharmacokinetics of Liposome Products:
Markers for Determination of Pharmacokinetics - Kinetics of Release of Liposomal in Tissues - Interactions of Liposomes with Cells - Route of Administration-Dependent Pharmacokinetics - Liposomes with Prolonged Circulation Times
* Pharmaceutical Applications of Liposomes:
Interactions of Liposomes with Cells - Liposomal Routes of Administration - Liposomal Applications - Liposome Toxicity
* Targeting of Liposomes:
Passive Targeting - Active Targeting - Pharmacokinetics of Site-Specific Drug Delivery - Targeting of pH-Sensitive Liposomes
* Industrial Applications of Liposomes:
Large-Scale Production - Removal of Nonencapsulated Drug - Freeze-Drying - Quality Control - Stability - Physical Stability - Chemical Stability - Sterilization

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