148 Pages
    by CRC Press

    Guide to current liposome drug delivery technology. Applications, preparation, pharmacokinetics, stability, passive and active targeting, and industrial production. Special emphasis on "stealth" liposomes (liposomes with extended circulation times).

    * Preparation of Liposomes:
    Materials - Lipid Selection - Selection of Method of Preparation - Characterization
    * Stability of Liposomes:
    Loss of Entrapped Drug - Changes in Liposome Structure - Phospholipid and Cholesterol Stability - Factors Affecting Liposome Stability - Freezing of Liposomes - Lyophilization
    * Pharmacokinetics of Liposome Products:
    Markers for Determination of Pharmacokinetics - Kinetics of Release of Liposomal in Tissues - Interactions of Liposomes with Cells - Route of Administration-Dependent Pharmacokinetics - Liposomes with Prolonged Circulation Times
    * Pharmaceutical Applications of Liposomes:
    Interactions of Liposomes with Cells - Liposomal Routes of Administration - Liposomal Applications - Liposome Toxicity
    * Targeting of Liposomes:
    Passive Targeting - Active Targeting - Pharmacokinetics of Site-Specific Drug Delivery - Targeting of pH-Sensitive Liposomes
    * Industrial Applications of Liposomes:
    Large-Scale Production - Removal of Nonencapsulated Drug - Freeze-Drying - Quality Control - Stability - Physical Stability - Chemical Stability - Sterilization


    Guru V. Betageri, Scott Allen Jenkins, Daniel Parsons