Lithium in Neuropsychiatry The Comprehensive Guide

Foreword

K.R Jamison (Baltimore, USA)

Preface

M Bauer, P Grof & B Muller-Oerlinghausen

SECTION A – Introduction, History

1. Lithium: a fascinating element in neuropsychiatry.

P.C. Whybrow (Los Angeles, USA)

2. History of lithium’s discovery

M. Schou (Aarhus, Denmark) & P. Grof (Ottawa, Canada)

3. History of Lithium’s use in North America

S.Gershon (Pittsburgh, USA)

4. Different views on the use of Lithium across continents

F.Goodwin (Washington, USA)

5. Lithium in international and national guidelines

B. Muller-Oerlinghausen & M Bauer (Berlin, Germany)

6. Lithium treatment: user’s perspective

Mary Lou Selo (New York, USA)

SECTION B. CLINICAL APPLICATIONS

B.1 – Mood and related disorders

7. Use of lithium in acute mania

R.Llicht (Aarhus, Denmark)

8. Use of lithium in maintenance treatment of bipolar disorder

J Geddes & G Goodwin (Oxford, UK)

9. Effectiveness of Lithium in naturalistic settings

M.Maj (Naples, Italy)

10. Use of lithium in maintenance treatment of unipolar affective disorder

JM Davis (Chicago, USA)

11. Efficacy in the treatment of acute unipolar and bipolar depression

M Bauer & T Bschor (Berlin, Germany)

12. Use of lithium in schizoaffective and schizophrenic disorders

C.Baethge (Koln, Germany) & C Simhandl (Neunkirchen, Austria)

13. Lithium in rapid cycling bipolar disorder

J.Calabrese (Cleveland, USA) & Michael Bauer (Berlin, Germany)

14. Excellent responders, subtyping, predictors of response

P.Grof (Ottawa, Canada)

15. Suicide-preventive and mortality reducing activity

B.Müller-Oerlinghausen (Berlin, Germany), B.Ahrens &

W.Felber (Dresden, Germany)

16. Treatment of lithium non-responders

W. Greil & N Kleindienst (Zurich, Switzerland)

B.2 Special populations and applications in medicine

17. Children, adolescents and off-spring

A.Duffy (Ottawa, Canada)

18. Lithium in geriatric populations

L.Gyulai & R. Young (Philadelphia, USA)

19. Women and lithium treatment (contraception, pregnancy & teratogenety)

B. Schmitz (Berlin, Germany)

20. Applications of lithium in medical conditions (hyperthyroidism, anti-viral activity, & cluster headache)

T. Bschor (Berlin, Germany), U. Lewitzka, & M. Adli (Dresden, Germany)

B.3 Effects on Body Systems

21. Renal effects of lithium

M.Schou (Aarhus, Denmark) & D Kampf (Berlin, Germany)

22. Effects of lithium on the thyroid and endocrine glands

JH Lazarus (Cardiff, UK)

23. Neurological effects of lithium (incl. EEG)

U.Hegerl (Munich, Germany)

24. Effects of lithium on the cardiovascular and gastrointestinal systems, and on metabolic activity (body weight)

J.Rybakowski, A Suwalska (Poznan, Poland) & I Paclt (Prague, Czech Republic)

25. Dermatological effects of lithium

A Pfennig (Berlin, Germany) & D Deshauer (Ottawa, Canada)

C. Pharmacology and Mechanisms

26. Chemistry and biochemistry of the lithium ion

N.Birch (UK)

27. Pharmakokinetics

M.Alda (Halifax, Canada)

28. Interaction of lithium with neurotransmitter systems (5-HT and others)

G.Juckel (Berlin, Germany)

29. Signal transduction pathways

D. Van Calker (Freiburg, Germany)

30. Effects of lithium on gene regulation

L.T Young (Toronto, Canada)

31. Neurotrophic and neuroprotective effects of lithium

H.Manji (Bethesda, USA)

32. Potential use in neurodegenerative disorders

De-Maw Chuang (Bethesda, USA) & J Priller (Berlin, Germany)

33. Effects of lithium on immune function

VS Gallicchio (Lexington, USA)

34. Results from brain imaging studies

J.Soares (San Antonio, USA)

35. Genetics of excellent Lithium responder

M.Alda, P.Zvolshy & P.Grof

36. Effects on behaviour and cognition (animals and healthy humans)

R.Belmaker (Beer Sheva, Israel)

D. Practical Issues

37. Guidelines for its safe use (indications and contraindications, pre-treatment investigations, dosing, investigations during long-term treatment, prevention and precaution of intoxication and other adverse events- e.g. body weight increase combination with other medications)

A.Berghöfer (Berlin, Germany), P Grof & B. Müller-Oerlinghausen

38. Latency and discontinuation issues (rebound phenomena, loss of efficacy after discontinuation)

R.Baldessarini (Boston, USA) L. Tondo & C.Baethge

39. Compliance and adherence during long-term treatment

P.Vestergaard (Aarhus, Denmark) & K.Thau (Vienna, Austria)

40. Lithium intoxication: signs and treatment

Intensive Care Physician & Psychiatrist T.B.A

41. Lithium Information Center of the Madison Institute of Medicine

JW Jefferson & JH Griest (Madison, USA)

42. Economics of lithium prophylaxis

A.Berghöfer (Berlin, Germany)

Appendices

Biography

Michael Bauer, Paul Grof, Bruno Muller-Oerlinghausen

"This is a superb, comprehensive, and essential book on the medical and psychiatric uses of lithium."

"This is an excellent and long needed book on the use of lithium. No resident should be allowed to finish training without knowing the information contained in this book. It should be required reading for all psychiatrists who treat seriously mentally ill patients."
Michael J. Schrift, Doody's Reviews, February 2007

"This well written book provides an authoritative and comprehensive synopsis of lithium use in various neuropsychiatric disorders. Written primarily for clinicians, this book should also appeal to interested researchers, psychopharmacologists, and experts in mood disorders. The book’s major strength is the depth of information and the breadth of subject material discussed. In hardcover, the text is attractive in layout and is free of production errors. Each chapter is followed by an exhaustive list of references. Given the amount of material covered and the size of the book, it is reasonably priced." - Verinder Sharma, Canadian Journal of Psychiatry 2006