This book presents state-of-art information summarizing the current understanding of a range of liver diseases, and reviews some key diagnostic and therapeutic advances. The book is a collection of selected clinical and scientific topics divided into two volumes, each divided into two sections. The first volume treats the cellular, biochemical and immunological mechanisms underlying liver diseases; the second focuses on clinical liver disease pathophysiology and related diagnostics and therapeutic insights. It is hoped that the target readers - hepatologists, clinicians, researchers and cademicians - will be exposed to new ideas, and subjects beyond their own scientific disciplines. In addition, students and all those who wish to enlarge their knowledge of advances in the field of liver diseases will find this book a good source of information.
VOLUME 1: LIVER DISEASES: PATHWAYS, MEDIATORS AND REGULATION : Section I: Liver Diseases: Mediators and Regulation: Ubiquitin - Proteasome Pathway in the Pathogenesis of Liver Disease; Bardag-Gorce; Collagen Gene Regulation in the Hepatic Stellate Cell; Rippe; CYP2F1-Biochemical and Toxicological Aspects and Role in Alcohol-induced Liver Injury; Cederbaum; Alcohol and Methyl Transfer: Implications for Alcohol-Related Hepatocarcinogenesis; Menthionine Adenosyltransferase and S-adenosylmethionine in Liver Health and Disease; Acetone Metabolism in the Liver; Oxidative Stress and Liver Fibrosis: From Liver Injury to Modulation of Cell Signalling and Response; Role of Nitric Oxide in Liver Disorders; Renin-Angiotensin System in Liver Fibrosis�Section II: Immunological Basis of Liver Injury: Cell and Molecular Mechanisms in the Development of Chronic Liver Inflammation; Role of Activated Macrophages in Liver Disease; Investigations into Basis for Immune Recognition of Cellular Targets in Primary Biliary Cirrhosis; Cross Talk of Hepatocytes and Nonparenchymal Liver Cells in Physiology and Pathology: Monoxides and Eicosanoids; Activity of Cytokines in Chronic HCV Infection and Influence of Antiviral Drugs; Role of Chemokines in Liver Pathophysiology�VOLUME 2: CLINICAL LIVER DISEASES: PATHOPHYSIOLOGY, DIAGNOSTIC AND THERAPEUTIC INSIGHTS: Section III: Clinical Liver Disease Pathophysiology: Nonalcoholic Fatty Liver Diseases: Clinical and Pathophysiological Features; Genetic Basis of Hepatocellular Cancer; Haemochromatosis: Recent Advances; Pathophysiology of Cirrhotic Ascites: Recent Advances; Cryptogenic Hepatitis; HIV-1 and the Liver; Cell Death by Necrosis: Mechanisms and Interception in the Liver; Fulminant Hepatic Failure: Etiology, Pathogenesis, and Treatment�Section IV: Therapeutic and Diagnostic Insights: Advances in Biology and Therapy of Hepatitis B Virus Infection; Hepatitis C Virus: Molecular Virology and Therapeutic Targets; Drug Targeting to Hepatic Stellate Cells: A New Strategy to Treat Liver Fibrosis; Developing Therapeutic Strategies for Hepatic Fibrosis; Liver Disease, Oxidative Stress and Ursodeoxycholic Acid; Plasma TGF-b as a Diagnostic and Prognostic Marker; Hepatocytes as the Gold Standard for Predicting in-vivo Hepatotoxicity of Xenobiotics Using Accelerated Cytotoxicity Mechanism Screening Techniques