Nonalcoholic fatty liver disease is one of the most common liver diseases worldwide affecting patients from all ages, races, and ethnic backgrounds. It comprises a spectrum of hepatic pathology ranging from simple steatosis, in which there is an increase of fat accumulation in hepatocytes, to nonalcoholic steatohepatitis and cirrhosis. The significant prevalence of this disease—between 15 and 45 percent of the general population—means that it contributes to an increased burden of ill health both today and in the future.
Liver Metabolism and Fatty Liver Disease addresses the current understanding of the development of nonalcoholic fatty liver disease as well as the clinical aspects of the disease by examining the current knowledge surrounding metabolism in the liver. The book discusses various topics including the involvement of oxidative stress, metabolic effects, and inflammation as well as the effect of nutrition on the development and progression of the disease.
Table of Contents
Introduction to Fatty Liver Disease and Consequences
Clinical Aspects of Nonalcoholic Fatty Liver Disease; Noa Mashav and Oren Shibolet
Fatty Liver Disease and Consequences
Fatty Liver Vulnerability to Hypoxic and Inflammatory Stress; Rabindra Dhital and Oren Tirosh
Development of Hepatocellular Carcinoma; A. Ruth He and Lopa Mishra
Cellular Stress Responses in the Regulation of Drug-Induced Liver Steatosis; Dotan Uzi, Duah Alkam, and Boaz Tirosh
The Role of the Keap1/Nrf2 Pathway in the Development and Progression of Nonalcoholic Fatty Liver Disease; Dionysios V. Chartoumpekis and Thomas W. Kensler
Methionine Adenosyltransferase Genes in Liver Health and Disease; Komal Ramani and Shelly C. Lu
Role and Modulation of Nitric Oxide in the Cirrhotic Liver; Jordi Gracia-Sancho, Juan Carlos García-Pagán, and Jaime Bosch
Role of Mitochondria in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease; Nicole Rubin, Ho Leung, Jacob E. Valk, Stephen M. Wertheimer, and Derick Han
Nutrition Role in Liver Protection and Damage
Nutritional Induction of Nonalcoholic Fatty Liver Disease; Noga Budick-Harmelin, Michal Aharoni-Simon, and Zecharia Madar
The Double-Edged Sword of Hepatic Iron Metabolism in Health and Diseases; Guiliano Ramadori and Ihtzaz Ahmed Malik
Diet and Lifestyle Changes as Treatment for Nonalcoholic Fatty Liver Disease; Shira Zelber-Sagi
Role of Antioxidants in the Nonalcoholic Fatty Liver Disease Spectrum; Tommy Pacana and Arun J. Sanyal
ω-3 Fatty Acids and Nonalcoholic Fatty Liver Disease; Christopher M. Depner, Kelli A. Lytle, Sasmita Tripathy, and Donald B. Jump
Nutraceuticals in the Prevention and Treatment of Fatty Liver Disease; Anna Aronis
Oren Tirosh is an associate professor at the School of Nutrition Science in the Institute of Biochemistry, Food Science and Nutrition at The Hebrew University of Jerusalem. He received his PhD from the School of Pharmacy at The Hebrew University of Jerusalem and completed a postdoctoral fellowship at the University of California, Berkeley. Dr. Tirosh is a lifetime honorary member in the Oxygen Club of California and is active in the board of The Israel Society for Oxygen and Free Radical Research. His research interests include nitric oxide and redox biology, oxidative stress and liver pathology, and lipid metabolism under liver disease conditions.