1st Edition
Local Drug Delivery for Coronary Artery Disease Established and Emerging Applications
608 Pages
125 B/W Illustrations
by
CRC Press
622 Pages
by
CRC Press
Also available as eBook on:
Restenosis remains the Achilles heel of Percutaneous Coronary Interventions. Numerous pharmacological agents have been tested in order to reduce acute thrombosis and the hyperproliferative cellular response, and drug eluting stents-using the stent as a platform for local drug delivery-are now considered a significant breakthrough in interventional cardiology. Pioneers in the field, the editors of... Read more
GENERAL INTRODUCTION
Introduction
Purposes of the Site-specific Therapy: Arterial Wall Passivation
Local Drug Delivery: Impact of Pressure, Substance Characteristics and Stenting on Drug Transfer Into the Arterial Wall
SYLLABUS OF THE PLATFORMS FOR LOCAL VASCULAR DRUG DELIVERY
Catheter-based and Stent-based Treatment for Coronary Artery Disease
The ClearWay™ Microporous Balloon Catheter
DISPATCH® Coronary Infusion Catheter
REMEDY™ PTCA Dilation Infusion Catheter
Infiltrator angioplasty Balloon Catheter
The Infiltrator™ Local Drug Delivery Catheter
The Needle Catheter
Stent Mediated Local Drug Delivery
INERT AND NON-ELUTING COATINGS
Silicon Carbide-coated Stents
Carbostent: A Carbofilm™ Coated Stent
The PC-coated BiodivYsio™ Stent
PTFE Covered Stent
DRUG ELUTING COATINGS
Overview about Drug Delivery Coatings
Phosphorylocholine (PC Technology™) Coated stents as a Drug Delivery Platform
Direct Stent Coating: An Alternative for Polymers?
Radioactive Stents
SYLLABUS OF THERAPEUTIC AGENTS
Overview of Potential Interesting Drugs to Inhibit in-stent Restenosis
Direct Antithrombins
Tissue Factor Inhibitors
Nitric Oxide Related Interventions and Restenosis
Vitamin E and its Multiple Properties: Anti, Pro, and Non-oxidative Activities
Dexamethasone Eluting Stent
Anti-inflammatory Approaches to Restenosis
The Role of Matrix Metalloproteinases Inhibitors after Arterial Injury
Methotrexate: A Potential Interesting Drug for Stent Mediated Local Drug Delivery anti-inflammatory and anti Proliferative Characteristics
Actin-skeleton Inhibitors: Poetential Candidates for Local Drug Delivery in the Prevention of an In-stent Restenosis?
Local Delivery of Antisense Oligomers to c-myc for the Prevention of Restenosis
PRE-CLINICAL STUDIES
Character-based Intravascular Delivery
Stent-based Intravascular Delivery
CLINICAL STUDIES
Catheter-based Local Heparin Delivery
Local Delivery of Low Molecular Weight Heparins
Local Delivery of Steroids before Coronary Stent Implantation
Clinical Studies with the Carbostent
Gold Coated Stents
Heparin-coated Stent trials
The Blue Medical 50% TEMPO Coronary Stent: Pre-clinical Study and the First In-man Pilot Trial
Dexamethasone: Mode of action, Pre-clinical and Clinical Studies
ß-edstradiol Eluting Stents - A Potential Therapy in the Prevention of Restenosis
Batimastat: Mode of Action, Preclinical and Clinical Studies
FIM Trial
Tacrolimus Eluting Stents
Everolimus Eluting Stents
Endeavor Drug-eluting Stent Systems
The Quanam Drug-eluting Stent and the SCORE Trial
The Boston Scientific Paclitaxel-eluting Stent: TAXUS I and II
Clinical Results with Non-polymer Based Taxol-eluting Stents: The European EvaLUation of pacliTaxel Eluting Stent (ELUTES) Trial
ALTERNATIVE METHODS FOR LOCAL VCASCULAR DRUG DELIVERY
Intrapericardial Drug Delivery for Prevention of Restenosis
Alternatives to Drug-eluting Stents: Safety and Efficacy of Systemic Delivery of Anti-proliferative Therapy to Reduce In-stent Neointimal Hyperplasia
LOCAL DRUG DELIVERY: A CRITICAL PERSPECTIVE
Drug-eluting Stents: A Critical Perspective
Introduction
Purposes of the Site-specific Therapy: Arterial Wall Passivation
Local Drug Delivery: Impact of Pressure, Substance Characteristics and Stenting on Drug Transfer Into the Arterial Wall
SYLLABUS OF THE PLATFORMS FOR LOCAL VASCULAR DRUG DELIVERY
Catheter-based and Stent-based Treatment for Coronary Artery Disease
The ClearWay™ Microporous Balloon Catheter
DISPATCH® Coronary Infusion Catheter
REMEDY™ PTCA Dilation Infusion Catheter
Infiltrator angioplasty Balloon Catheter
The Infiltrator™ Local Drug Delivery Catheter
The Needle Catheter
Stent Mediated Local Drug Delivery
INERT AND NON-ELUTING COATINGS
Silicon Carbide-coated Stents
Carbostent: A Carbofilm™ Coated Stent
The PC-coated BiodivYsio™ Stent
PTFE Covered Stent
DRUG ELUTING COATINGS
Overview about Drug Delivery Coatings
Phosphorylocholine (PC Technology™) Coated stents as a Drug Delivery Platform
Direct Stent Coating: An Alternative for Polymers?
Radioactive Stents
SYLLABUS OF THERAPEUTIC AGENTS
Overview of Potential Interesting Drugs to Inhibit in-stent Restenosis
Direct Antithrombins
Tissue Factor Inhibitors
Nitric Oxide Related Interventions and Restenosis
Vitamin E and its Multiple Properties: Anti, Pro, and Non-oxidative Activities
Dexamethasone Eluting Stent
Anti-inflammatory Approaches to Restenosis
The Role of Matrix Metalloproteinases Inhibitors after Arterial Injury
Methotrexate: A Potential Interesting Drug for Stent Mediated Local Drug Delivery anti-inflammatory and anti Proliferative Characteristics
Actin-skeleton Inhibitors: Poetential Candidates for Local Drug Delivery in the Prevention of an In-stent Restenosis?
Local Delivery of Antisense Oligomers to c-myc for the Prevention of Restenosis
PRE-CLINICAL STUDIES
Character-based Intravascular Delivery
Stent-based Intravascular Delivery
CLINICAL STUDIES
Catheter-based Local Heparin Delivery
Local Delivery of Low Molecular Weight Heparins
Local Delivery of Steroids before Coronary Stent Implantation
Clinical Studies with the Carbostent
Gold Coated Stents
Heparin-coated Stent trials
The Blue Medical 50% TEMPO Coronary Stent: Pre-clinical Study and the First In-man Pilot Trial
Dexamethasone: Mode of action, Pre-clinical and Clinical Studies
ß-edstradiol Eluting Stents - A Potential Therapy in the Prevention of Restenosis
Batimastat: Mode of Action, Preclinical and Clinical Studies
FIM Trial
Tacrolimus Eluting Stents
Everolimus Eluting Stents
Endeavor Drug-eluting Stent Systems
The Quanam Drug-eluting Stent and the SCORE Trial
The Boston Scientific Paclitaxel-eluting Stent: TAXUS I and II
Clinical Results with Non-polymer Based Taxol-eluting Stents: The European EvaLUation of pacliTaxel Eluting Stent (ELUTES) Trial
ALTERNATIVE METHODS FOR LOCAL VCASCULAR DRUG DELIVERY
Intrapericardial Drug Delivery for Prevention of Restenosis
Alternatives to Drug-eluting Stents: Safety and Efficacy of Systemic Delivery of Anti-proliferative Therapy to Reduce In-stent Neointimal Hyperplasia
LOCAL DRUG DELIVERY: A CRITICAL PERSPECTIVE
Drug-eluting Stents: A Critical Perspective
Biography
Edoardo Camenzind and Ivan K De Scheerder
