Local Drug Delivery for Coronary Artery Disease: Established and Emerging Applications, 1st Edition (Hardback) book cover

Local Drug Delivery for Coronary Artery Disease

Established and Emerging Applications, 1st Edition

Edited by Edoardo Camenzind, Ivan De Scheerder

CRC Press

608 pages | 75 Color Illus. | 125 B/W Illus.

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Hardback: 9781841840451
pub: 2005-06-14
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Description

Restenosis remains the Achilles heel of Percutaneous Coronary Interventions. Numerous pharmacological agents have been tested in order to reduce acute thrombosis and the hyperproliferative cellular response, and drug eluting stents-using the stent as a platform for local drug delivery-are now considered a significant breakthrough in interventional cardiology.

Pioneers in the field, the editors of Local Drug Delivery for Coronary Artery Disease have assembled an excellent team of contributors who offer their experience with threatened vessel closure and restenosis, acute thrombosis, hyperproliferative cellular response, stents and local drug delivery. They share their expertise on all aspects of the field, including a discussion of results from preclinical and clinical studies, and they examine alternative methods of molecular delivery to the vessel wall.

With coverage of the most current methods and applications, as well as a host of photographs illustrating their implementation, this book will serve as an excellent reference for cardiologists, pharmacologists, cardiac surgeons, and trainees.

Table of Contents

GENERAL INTRODUCTION

Introduction

Purposes of the Site-specific Therapy: Arterial Wall Passivation

Local Drug Delivery: Impact of Pressure, Substance Characteristics and Stenting on Drug Transfer Into the Arterial Wall

SYLLABUS OF THE PLATFORMS FOR LOCAL VASCULAR DRUG DELIVERY

Catheter-based and Stent-based Treatment for Coronary Artery Disease

The ClearWay™ Microporous Balloon Catheter

DISPATCH® Coronary Infusion Catheter

REMEDY™ PTCA Dilation Infusion Catheter

Infiltrator angioplasty Balloon Catheter

The Infiltrator™ Local Drug Delivery Catheter

The Needle Catheter

Stent Mediated Local Drug Delivery

INERT AND NON-ELUTING COATINGS

Silicon Carbide-coated Stents

Carbostent: A Carbofilm™ Coated Stent

The PC-coated BiodivYsio™ Stent

PTFE Covered Stent

DRUG ELUTING COATINGS

Overview about Drug Delivery Coatings

Phosphorylocholine (PC Technology™) Coated stents as a Drug Delivery Platform

Direct Stent Coating: An Alternative for Polymers?

Radioactive Stents

SYLLABUS OF THERAPEUTIC AGENTS

Overview of Potential Interesting Drugs to Inhibit in-stent Restenosis

Direct Antithrombins

Tissue Factor Inhibitors

Nitric Oxide Related Interventions and Restenosis

Vitamin E and its Multiple Properties: Anti, Pro, and Non-oxidative Activities

Dexamethasone Eluting Stent

Anti-inflammatory Approaches to Restenosis

The Role of Matrix Metalloproteinases Inhibitors after Arterial Injury

Methotrexate: A Potential Interesting Drug for Stent Mediated Local Drug Delivery anti-inflammatory and anti Proliferative Characteristics

Actin-skeleton Inhibitors: Poetential Candidates for Local Drug Delivery in the Prevention of an In-stent Restenosis?

Local Delivery of Antisense Oligomers to c-myc for the Prevention of Restenosis

PRE-CLINICAL STUDIES

Character-based Intravascular Delivery

Stent-based Intravascular Delivery

CLINICAL STUDIES

Catheter-based Local Heparin Delivery

Local Delivery of Low Molecular Weight Heparins

Local Delivery of Steroids before Coronary Stent Implantation

Clinical Studies with the Carbostent

Gold Coated Stents

Heparin-coated Stent trials

The Blue Medical 50% TEMPO Coronary Stent: Pre-clinical Study and the First In-man Pilot Trial

Dexamethasone: Mode of action, Pre-clinical and Clinical Studies

ß-edstradiol Eluting Stents - A Potential Therapy in the Prevention of Restenosis

Batimastat: Mode of Action, Preclinical and Clinical Studies

FIM Trial

Tacrolimus Eluting Stents

Everolimus Eluting Stents

Endeavor Drug-eluting Stent Systems

The Quanam Drug-eluting Stent and the SCORE Trial

The Boston Scientific Paclitaxel-eluting Stent: TAXUS I and II

Clinical Results with Non-polymer Based Taxol-eluting Stents: The European EvaLUation of pacliTaxel Eluting Stent (ELUTES) Trial

ALTERNATIVE METHODS FOR LOCAL VCASCULAR DRUG DELIVERY

Intrapericardial Drug Delivery for Prevention of Restenosis

Alternatives to Drug-eluting Stents: Safety and Efficacy of Systemic Delivery of Anti-proliferative Therapy to Reduce In-stent Neointimal Hyperplasia

LOCAL DRUG DELIVERY: A CRITICAL PERSPECTIVE

Drug-eluting Stents: A Critical Perspective

Subject Categories

BISAC Subject Codes/Headings:
MED010000
MEDICAL / Cardiology