1st Edition

Long Term Safety of Assisted Reproduction

    222 Pages 10 B/W Illustrations
    by CRC Press

    222 Pages 10 B/W Illustrations
    by CRC Press

    A much-needed overview of the available information now accumulating to indicate that assisted reproductive technologies are generally safe for both babies and mothers. However, the literature abounds with reports of a higher risk of obstetric and perinatal complications; regarding the long term outcomes for both women and children, the data are still scarce. The chapters summarized in this book review the current knowledge on long term safety of assisted reproduction and indicate the need for continued research to cover the lack of data in some specific patient groups and for recently developed treatments that only have a short period of follow-up.


    List of Contributors

    1 The Effect of Ovarian Stimulation on Short Term Maternal Outcomes
    Carol Coughlan, Barbara Lawrenz, and Human Fatemi
    2 Evidence of the long-term safety of ART and fertility drugs regarding cancer risk
    Frida E Lundberg
    3 Maternal and obstetrical outcomes after IVF indicated by a male factor
    Begoña Prieto and Maria Diaz-Nuñez
    4 The long-term outcomes of children conceived through ART
    Kenny Rodriguez-Wallberg and Panagiotis Tsiartas
    5 Maternal and obstetrical outcomes after transfer of cryopreserved embryos
    Anne Lærke Spangmose, Anna-Karina Aaris Henningsen, and Anja Pinborg
    6 Safety of Assisted Reproduction and fertility preservation in women with Turner Syndrome
    Kenny A. Rodriguez-Wallberg
    7 Maternal and obstetrical outcomes after oocyte cryopreservation
    Alessandra Alteri and Valerio Pisaturo
    8 Perinatal complications in pregnancies achieved using donor oocytes
    Roberto Matorras, Héctor Sainz, and Ana Matorras
    9 Obstetrical risks and pregnancy outcomes specific to patients with very advanced maternal age (over 45)
    Filipa Rafael, Marta Carvalho, and Samuel Santos-Ribeiro
    10 Obstetric, perinatal, and post-natal outcomes after PGT
    Danilo Cimadomo, Letizia Papini, Nicoletta Barnocchi, Laura Rienzi, and Filippo Maria Ubaldi
    11 Multiple birth outcomes: A minimizing strategy for elective single embryo transfer [eSET]
    Zdravka Veleva
    12 Obstetrical outcomes after cancer treatment with or without ART
    Giulia Maria Cillo and Arianna D’Angelo
    13 An overview of ART and the risks of childhood cancer
    Julian Gardiner and Alastair Sutcliffe
    14 Obstetrical and perinatal outcomes following gestational surrogacy
    Marieke O. Verhoeven, Henrike E. Peters, and Cornelis B. Lambalk
    15 Birth outcomes of children born after treatments still considered innovative: in vitro oocyte maturation (IVM)
    Julie Labrosse, Daniela Nogueira, and Christophe Sifer
    16 An overview on the clinical outcomes from ovarian tissue cryopreservation
    Daniela Nogueira and Isabelle Demeestere
    17 In Vitro embryo development: Implications for epigenetic regulation
    Giovanni Coticchio and Andrea Borini
    18 Psychosocial effects of undergoing ART
    Sofia Gameiro and Bethan Rowbottom
    19 Psychosocial Adjustment in Offspring Conceived through ART: Childhood, Adolescence and Young Adulthood
    Catherine McMahon and Caitlin Macmillan
    20 The Long-Term Safety of ART: Ethical Aspects
    Lucy Frith, Heidi Mertes, and Nicola Jane Williams


    Arianna D’Angelo, MD, Associate MRCOG is Clinical Lead and Consultant in Reproductive Medicine, Wales Fertility Institute, Swansea Bay University Health Board; Senior Clinical Lecturer in Obstetrics and Gynaecology, Cardiff University, Cardiff, UK

    Kenny A. Rodriguez-Wallberg MD, PhD is Professor and Clinical Head, Programme for Fertility Preservation, Department of Oncology-Pathology, Karolinska Institutet; Laboratory of Translational Fertility Preservation, BioClinicum; Head of the Subspecialist Training Program in Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden

    Daniela Nogueira, PhD is Scientific Director, Groupe Inovie Fertilité; Co-Head, Centre AMP de la Clinique Croix du Sud, Toulouse, France