Lymphatic Transport of Drugs provides a thorough review of the determinants that affect the uptake and delivery of drugs and xenobiotics to the lymphatics. Factors affecting the transport and delivery of lipophilic drugs through the lymph after oral administration, lymphatic transport of polar drugs and macromolecules after gastrointestinal dosing, transport of drugs into the lymph after parenteral administration, and particulate drug delivery systems are among the topics examined in this volume. Lymphatic Transport of Drugs is primarily intended for pharmaceutical scientists who are attempting to alter the delivery of current therapeutic agents through formulation of prodrugs, as well as for researchers designing new drugs for lymph delivery.
Introduction/Preface (W. N. Charman and V. J. Stella). Anatomy and Physiology of the Lymphatics (C.M. O'Driscoll). Intestinal Processing of Dietary Lipids (C.M. Mansbach,II). Methodologies for the Assessing Intestinal Lymphatic Transport (T.J. Raub, S.L. Douglas, G.W. Melchior, W.N. Charman, and W. Morozowich). Lipid Vehicle and Formulation Effects on Intestinal Lymphatic Drug Transport (W.N. Charman). Lipophilic Prodrugs and the Promotion of Intestinal Lymphatic Drug Transport (V.J. Stella and N.L. Pochopin). The Clearance of Lipoproteins and of Drugs Associated with Lipoproteins (T. Noguchi). Lymphatic Transport of Polar Drugs After Gastrointestinal Dosing (H. Yoshikawa and S. Muranishi). Lymphatic Transport After Parenteral Drug Administration (Y. Takakura, M. Hashida, and H. Sezaki). Particulates and Lymphatic Drug Delivery (D.T. O'Hagan, N.M. Christy, and S.S. Davis).