Malaria causes more death and disease than any other parasitic pathogen known today. This multiauthored text covers the important areas of malaria research, particularly focusing on those sectors which are of clinical importance for the understanding of the disease, the parasite, and its vector.
The chapter authors are all leading experts within their own particular fields. The biology and molecular biology of the parasite, the clinical spectrum of the disease, the pathogenesis of malaria, and the immunology and emergence of malaria vaccines are some examples of the scientific spheres that are discussed.
The book is suitable as a text for graduate students and clinicians as well as researchers at universities and companies involved in treating or studying infectious diseases.
Table of Contents
1. Milestones and Millstones in the History of Malaria 2. What Is Malaria? 3. The Malaria Parasite and Life-cycle 4. The Epidemiology of Malaria 5. Clinical Features of Malaria 6. Molecular Malariology 7. The Anopheles Mosquito: Genomics and Transformation 8. The Malaria Genome 9. The Malaria Antigens 10. Genetic Approaches to the Determinants of Drug Response, Pathogenesis and Infectivity in Plasmodium Falciparum Malaria 11. The Sporozoite, the Merozoite and the Infected Red Cell: Parasite Ligands and Host Receptors 12. Pathogenesis and Resistance 13. Cytoadherence and Rosetting in the Pathogenesis of Severe Malaria 14. Inflammatory Processes in the Pathogenesis of Malaria 15. Inborn Resistance to Malaria 16. Burkett's Lymphoma and Malaria 17. Malaria Immunology and Vaccines 18. The Role of T Cells in Immunity to Malaria and the Pathogenesis of Disease 19. Malaria Vaccines 20. Synthetic Peptides as Malaria Vaccines 21. SPf66: The First and Towards the Second Generation of Malarial Vaccines